Robert Orchard

Learn More
Two medical data sets (Breast cancer and Colon cancer) are investigated within a visual data mining paradigm through the unsupervised construction of virtual reality spaces using genetic programming and classical optimization (for comparison purposes). The desired visual spaces are such that a modified genetic programming approach was proposed in order to(More)
  • John G. Doench, Nicolo Fusi, Meagan Sullender, Mudra Hegde, Emma W. Vaimberg, Katherine F. Donovan +7 others
  • 2016
CRISPR-Cas9-based genetic screens are a powerful new tool in biology. By simply altering the sequence of the single-guide RNA (sgRNA), one can reprogram Cas9 to target different sites in the genome with relative ease, but the on-target activity and off-target effects of individual sgRNAs can vary widely. Here, we use recently devised sgRNA design rules to(More)
The aim of the Integrated Diagnostic System (IDS) project is to research, develop and test advanced diagnostic and decision support tools for maintenance of complex machinery. This paper provides an overview of the hybrid reasoning conducted within this system with particular reference to Case-Based Reasoning (CBR) and its integration in this environment.(More)