Twenty 6- to 17-year-old children with neurofibromatosis 1. (NF1) were compared to 20 age- and sex-matched siblings on a wide range of neuropsychological and behavioral dimensions. In familial cases, diagnostic status was confirmed by gene linkage with greater than 98% accuracy. Visual examinations that included assessments of visual evoked responses (VER)… (More)
There is little longitudinal data examining outcome of pediatric near-drowning. Most literature tracks status 5 years or less post insult, focusing primarily on gross neurologic status as opposed to more subtle neurocognitive deficits. The present case tracks the neuropsychological profile of a child who was submerged for 66 min, the longest time… (More)
Optic pathway gliomas (OPGs) occur in 15%-20% of children with neurofibromatosis type 1 (NF1); up to half become symptomatic. There is little information regarding ophthalmologic outcomes after chemotherapy. A retrospective multicenter study was undertaken to evaluate visual outcomes following chemotherapy for NF1-associated OPG, to identify risks for… (More)
PURPOSE While the role of the macular pigment carotenoids in the prevention of age-related macular degeneration has been extensively studied in adults, comparatively little is known about the physiology and function of lutein and zeaxanthin in the developing eye. We therefore developed a protocol using a digital video fundus camera (RetCam) to measure… (More)
PURPOSE Deposition of the macular pigment carotenoids lutein and zeaxanthin in the human retina occurs early in life. In this study, we examined the interrelationships of maternal carotenoid status and newborn infant macular pigment levels and systemic carotenoid status. As a secondary measure, we also evaluated the effects of intrauterine growth… (More)
In his very informative and thoughtful discussion of a patient with copper deficiency, Dr Samuels refers to the checklist concept in considering the differential diagnosis. He cites a Google search of myeloneuropathy and malnutrition as helping in suggesting the diagnosis. 1 He further notes that searching on common nonspecific neurologic signs and symptoms… (More)
Intravitreal injections of botulinum A toxin in two doses, 1.25 and 25 units, were performed in two rabbit eyes. The fellow eyes were injected with an equal volume of saline to serve as controls. The visual evoked potential was unchanged at one and two weeks post-injection when compared to pre-injection recordings in both botulinum and saline injected eyes.