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OBJECTIVES The purpose of this study was to investigate the effectiveness and costs of incorporating a parent-completed developmental screening tool, the Ages and Stages Questionnaire, into the 12- and 24-month well-child visits under "real-world" conditions, using a combined in-office and mail-back data collection protocol. METHODS A convenience sample(More)
The development of nine infants with enlarged subarachnoid spaces identified by specific CT-scan criteria was prospectively followed to two to three years of age. Infants with intracranial hemorrhage, CNS anomaly, microcephaly or other factors of potentially major negative impact on their development were excluded. All study infants had normal or only(More)
Approximately 5% of children with neural tube defects (NTDs) have a congenital heart defect and/or cleft lip and palate. The cause of isolated meningomyelocele, congenital heart defects, or cleft lip and palate has been largely thought to be multifactorial. However, chromosomal, teratogenic, and single gene causes of combinations of NTDs with congenital(More)
Twenty-five of the 45 long-term survivors with birth weights of 1,000 g or less who were cared for in the University of Washington, Seattle, Neonatal Intensive Care Unit from 1960 to 1972 were examined at a mean age of 10.6 years. Seven of the 25 children (28%) had one or more major neurologic or sensory handicaps. Sixteen (64%) have been or presently are(More)
The authors describe the Infant Motor Screen, which is a brief evaluation of the quality of motor patterns of preterm infants from four to 16 months of age. It was developed for use with an assessment of motor milestones as part of a developmental screening program for high-risk infants. 111 infants were tested at four months and 58 at eight months. The(More)
Recently we reported on three unrelated children with neural tube defects (NTDs) and deletion of 22q11. Two of these children have velo-cardio-facial syndrome and the third DiGeorge sequence. Thus, NTDs appear to be part of the clinical picture due to 22q11 deletion. To further explore this association and to clarify what findings should prompt testing for(More)
Central ventilatory dysfunction (CVD) is a significant complication of myelodysplasia with Arnold-Chiari type II defect. The records of 616 patients with myelodysplasia were reviewed and CVD was documented in 35 cases (5.7 per cent): it was the single most common cause of death in this population. There was no significant association between CVD and level(More)
We report on the successful prenatal diagnosis of the late infantile "Jansky-Bielschowsky" variant of the neuronal ceroid-lipofuscinoses (NCL). The fetus was studied at 16 weeks of gestation because of an affected sib. Uncultured amniotic fluid cells were studied by conventional electron microscopic techniques. About one-third of a subpopulation of dark,(More)