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Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies.
TLDR
It is postulate that decreased placental growth factor production results in abnormalities of placental angiogenesis through direct and indirect effects on other vasculotropic growth factors.
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Glycodelin: a major lipocalin protein of the reproductive axis with diverse actions in cell recognition and differentiation.
TLDR
Along with being an epithelial differentiation marker, glycodelin appears to play a role in glandular morphogenesis, as transfection of gly codelin cDNA into a glyCodelin-negative breast cancer cells resulted in formation of gland-like structures, restricted proliferation, and induction of other epithelial markers.
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First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia.
TLDR
First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE and not markedly differ between the groups.
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Endometrial decidualization: of mice and men.
TLDR
Genomic profiling of mouse and human endometrium has uncovered a complex yet highly conserved network of steroid-regulated genes that supports decidualization, and to advance the understanding of the mechanisms regulating implantation and better address the clinical challenges of infertility and endometrial diseases such as endometriosis.
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Bone Morphogenetic Protein 2 Functions via a Conserved Signaling Pathway Involving Wnt4 to Regulate Uterine Decidualization in the Mouse and the Human*
TLDR
A unique conserved pathway involving BMP2 and Wnt4 that mediates P-induced stromal decidualization in the mouse and the human is uncovered.
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Mechanistic and Therapeutic Implications of Angiogenesis in Endometriosis
TLDR
The clinical implications of angiogenesis in this condition are reviewed, potential antiangiogenic therapies that may become useful in the control or eradication of endometriotic lesions are proposed, and new data showing that oxidative and endoplasmic reticulum stress increase vascular endothelial growth factor expression are provided.
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Neonatal DNA methylation patterns associate with gestational age
TLDR
The results suggest neonatal DNA methylation varies with GA even in term deliveries, and the potential contribution of these changes to clinically significant postnatal outcomes warrants further investigation.
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Inflammation in Reproductive Disorders
TLDR
A better understanding of the necessary role of inflammation in reproduction will allow more rational and targeted treatment of inflammatory disorders in reproductive medicine.
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Endometriosis: the role of neuroangiogenesis.
TLDR
The mechanisms and therapeutic implications of neuroangiogenesis in these lesions are considered and potential treatments for the control or elimination of endometriosis-associated pain are proposed.
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Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition.
TLDR
A comprehensive synthesis of the mediators that contribute to the timing of human labor is provided, putting forth the core hypothesis that fetal membrane (amnion and chorion) senescence is the initiator of a coordinated, redundant signal cascade leading to parturition.
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