Robert Mahoney

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The mammalian target of rapamycin (mTOR) is a major component of the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway that is dysregulated in 50% of all human malignancies. Rapamycin and its analogues (rapalogs) partially inhibit mTOR through allosteric binding to mTOR complex 1 (mTORC1) but not mTOR complex 2 (mTORC2), an emerging player in cancer.(More)
We report a case of a 57-year-old woman who was diagnosed with a systemic AA amyloidosis associated with a pleomorphic sarcoma of the spleen. Although the association and causality between chronic inflammatory states and systemic AA amyloidosis have been well established, the evidence linking solid malignancies to reactive AA amyloidosis is scarce. Our(More)
Ebola hemorrhagic fever outbreaks occurred in 1 975-1 979 and 1994-1996 within tropical Africa. It was determined from Landsat satellite data that all outbreaks occurred in tropical forest with a range of human intrusions. Meteorological satellite data, spanning the 1981 to 2000 time period, showed that marked and sudden climate changes from drier to wetter(More)
Information on ice is important for shipping, weather forecasting, and climate monitoring. Historically, ice cover has been detected and ice concentration has been measured using relatively low-resolution space-based passive microwave data. This study presents an algorithm to detect ice and estimate ice concentration in clear-sky areas over the ocean and(More)
The Asian citrus psyllid (Diaphorina citri Kuwayama) is the insect vector of the bacterium Candidatus Liberibacter asiaticus (CLas), the pathogen associated with citrus Huanglongbing (HLB, citrus greening). HLB threatens citrus production worldwide. Suppression or reduction of the insect vector using chemical insecticides has been the primary method to(More)
Continuous monitoring of the surface temperature is critical to understanding and forecasting Arctic climate change; as surface temperature integrates changes in the surface energy budget. The sea-ice surface temperature (IST) has been measured with optical and thermal infrared sensors for many years. With the IST Environmental Data Record (EDR) available(More)
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