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  • E. Doherty, C. Fotsch, +16 authors M. Norman
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2007 (First Publication: 1 July 2007)
  • A series of novel 4-oxopyrimidine TRPV1 antagonists was evaluated in assays measuring the blockade of capsaicin or acid-induced influx of calcium into CHO cells expressing TRPV1. The investigation ofExpand
  • Timothy D. Cushing, Xiaolin Hao, +33 authors Daniela P. Metz
  • Medicine, Chemistry
  • Journal of medicinal chemistry
  • 2015 (First Publication: 8 January 2015)
  • The development and optimization of a series of quinolinylpurines as potent and selective PI3Kδ kinase inhibitors with excellent physicochemical properties are described. This medicinal chemistryExpand