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The whole-brain criterion of death was first formally proposed by the "Ad Hoc Committee of the Harvard Medical School to Examine the Definition of Brain Death" in a "Special Communication" published in JAMA in 1968. Since then, all states in the United States and many western countries have endorsed this definition of death. The strongest defense of the(More)
The Antarctic notothenioid Trematomus bernacchii (rock cod) lives at a constant mean temperature of -1.9 degrees C. Gastric digestion under these conditions relies on the proteolytic activity of aspartic proteases such as pepsin. To understand the molecular mechanisms of Antarctic fish pepsins, T. bernacchii pepsins A1 and A2 were cloned, overexpressed in(More)
BACKGROUND AND METHODS Problems with the clinical management of prostate cancer include the lack of both specific detection and efficient therapeutic intervention. We report the encapsulation of superparamagnetic iron platinum nanoparticles (SIPPs) and paclitaxel in a mixture of polyethyleneglycolated, fluorescent, and biotin-functionalized phospholipids to(More)
BACKGROUND Membrane receptors are frequent targets of cancer therapeutic and imaging agents. However, promising in vitro results often do not translate to in vivo clinical applications. To better understand this obstacle, we measured the expression differences in receptor signatures among several human prostate cancer cell lines and xenografts as a function(More)
Superparamagnetic iron oxide nanoparticles (SPIONs) are the most common type of contrast agents used in contrast agent-enhanced magnetic resonance imaging (MRI). Still, there is a great deal of room for improvement, and nanoparticles with increased MRI relaxivities are needed to increase the contrast enhancement in MRI applied to various medical conditions(More)
In this paper there has been presented a more complete account of the results of experiments on 1233 virus. Included are details regarding its isolation; antigenic peculiarities; size and morphology; behavior in embryonated eggs; agglutination of chicken erythrocytes; infectivity for laboratory animals; and relation to human infections. A review of the work(More)
There is evidence that amino acids 9-23 of the insulin B chain are a major target of anti-islet autoimmunity in type 1 diabetes. Administration of this peptide to NOD mice prevents diabetes, and phase I trials of an altered peptide ligand of B:9-23 are underway in humans. We were interested in long-term subcutaneous therapeutic administration of B:9-23(More)