Robert M. Shapiro

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Nocturnal rotational behavior was found to vary severalfold among Sprague-Dawley derived rats obtained from seven different breeders; net rotations per night (18 hours) varied from 5.0 to 31.0 in males and from 6.2 to 42.4 in females. Rats from three sources were tested twice (a week between tests) for rotation induced by d-amphetamine. Rats from two(More)
Rats received intrastriatal or intranigral injections of 6-hydroxydopamine (6-OHDA) on the same side towards which they made most of their turns during a previous test of amphetamine-induced rotational behavior. One week later they were retested for amphetamine-induced rotational behavior and it was found that only approximately half of them increased their(More)
Cocaine elicited dose-related rotation (circling) in naïve rats. The maximum effect was greater than observed previously with other drugs. Overall, females were more sensitive to cocaine than males. However, right-biased females were more sensitive than left-biased females, whereas left-biased males were more sensitive than right-biased males. The results(More)
We present a new approach to the study of work flows in organizations. Using well-known modeling paradigms and existing computer-based tools, we show how to rapidly model and analyze complex work structures to improve throughput and resource utilization. The specification of a work flow is done using IDEFO (SADT), extended with behavioral details. We have(More)
Long-term administration of the atypical neuroleptic clozapine (CLZ) poses a much lower risk of extrapyramidal side effects (EPS) than does the use of typical neuroleptics such as haloperidol (HAL). To investigate the neural mechanisms of the differing CNS activities of these two drugs, we used quantitative autoradiography to measure changes in dopamine and(More)
ABSTIL4CT Almost every BPR engagement begins with a 'process capture' phase. The BPR team goes to the process owners and with their assistance develops a complete description of how the business is currently conducted. The results of this are used to select those processes within the business which offer the potential for dramatic savings if re-engineered.(More)