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  • Shihua Sun, Cynthia C T Sprenger, +9 authors Stephen R. Plymate
  • Medicine, Biology
  • The Journal of clinical investigation
  • 2010 (First Publication: 2 August 2010)
  • Progression of prostate cancer following castration is associated with increased androgen receptor (AR) expression and signaling despite AR blockade. Recent studies suggest that these activities areContinue Reading
  • Scott M. Dehm, Lucy J. Schmidt, Hannelore V. Heemers, Robert L. Vessella, Donald J. Tindall
  • Medicine, Biology
  • Cancer research
  • 2008 (First Publication: 1 July 2008)
  • The standard systemic treatment for prostate cancer (PCa) is androgen ablation, which causes tumor regression by inhibiting activity of the androgen receptor (AR). Invariably, PCa recurs with a fatalContinue Reading
  • Elahe A. Mostaghel, Brett T. Marck, +5 authors Robert Bruce Montgomery
  • Medicine, Biology
  • Clinical Cancer Research
  • 2011 (First Publication: 1 August 2011)
  • Purpose: Abiraterone is a potent inhibitor of the steroidogenic enzyme CYP17A1 and suppresses tumor growth in patients with castration-resistant prostate cancer (CRPC). The effectiveness ofContinue Reading