Robert L. Wixom

Learn More
An intermediate reaction in valine biosynthesis is the dehydration of Q!, /3-dihydroxyisovaleric acid to ar-ketoisovaleric acid, which undergoes transamination to form valine. A similar catalytic removal of a molecule of water from cy , ,&dihydroxy-/3methyl-n-Valerie acid is a step in isoleucine formation. The dihydroxyacid dehydratase (EC 4.2.1.9) for(More)
The purpose of this 85-day study was to investigate the long-term effects of histidine depletion on nitrogen utilization in young adult men. A low nitrogen (6.3 g/day), low histidine (10 mg/day) amino acid diet was fed to seven men for 8 weeks. Mean nitrogen balance became negative at the end of the 8-week period. Free histidine in postabsorptive plasma and(More)
An adult male fed by parenteral alimentation for 48 days had successive intakes of a complete mixture of essential amino acids, and then lysine- and histidine deletion to test for the essentially of histidine. After 22 days of histidine-free-intake, 15NH4Cl was ingested orally with subsequent measurement of the time patterns for the appearance of 15N in(More)