Andrew N. Freedman2
Pamala A. Pawloski2
2Andrew N. Freedman
2Pamala A. Pawloski
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OBJECTIVE To assess the possible toxicity of thimerosal-containing vaccines (TCVs) among infants. METHODS A 2-phased retrospective cohort study was conducted using computerized health maintenance organization (HMO) databases. Phase I screened for associations between neurodevelopmental disorders and thimerosal exposure among 124 170 infants who were born(More)
BACKGROUND Clinical trials demonstrated that women treated for breast cancer with anthracycline or trastuzumab are at increased risk for heart failure and/or cardiomyopathy (HF/CM), but the generalizability of these findings is unknown. We estimated real-world adjuvant anthracycline and trastuzumab use and their associations with incident HF/CM. METHODS(More)
BACKGROUND Rare but serious adverse events associated with vaccines or drugs are often nearly impossible to detect in prelicensure studies and require monitoring after introduction of the agent in large populations. Sequential testing procedures are needed to detect vaccine or drug safety problems as soon as possible after introduction. OBJECTIVE To(More)
  • Simon J Hambidge, Jason M Glanz, Eric K France, David McClure, Stanley Xu, Kristi Yamasaki +13 others
  • 2006
CONTEXT Beginning with the winter season of 2004-2005, influenza vaccination has been recommended for all children 6 to 23 months old in the United States. However, its safety in young children has not been adequately studied in large populations. OBJECTIVE To screen for medically attended events in the clinic, emergency department, or hospital after(More)
OBJECTIVES Having shown previously that an electronic prescription writer and decision support system improved pediatric prescribing behavior for otitis media in an academic clinic setting, we assessed whether point-of-care delivery of evidence could demonstrate similar effects for a wide range of other common pediatric conditions. DESIGN Cluster(More)
Recent advances in genomic research have demonstrated a substantial role for genomic factors in predicting response to cancer therapies. Researchers in the fields of cancer pharmacogenomics and pharmacoepidemiology seek to understand why individuals respond differently to drug therapy, in terms of both adverse effects and treatment efficacy. To identify(More)
I n this month's issue of PLoS Medicine, Steele et al. address a timely question in clinical medicine today—how best to use the potential of computers to change and improve physicians' prescribing behavior [1]. In evaluating the effectiveness of automated computerized alerts in a primary-care setting, the authors examined a system that had been developed to(More)
Although rare, death from amanitin exposure poses a significant health risk and a diagnostic challenge to the clinician due to its rarity. This is one of the few conditions to be voluntarily reported by healthcare professionals. No antidote exists for this poisoning and, perhaps due to its rarity or lack of attention, the United States has lagged behind(More)
  • Renata J. M. Engler, Michael R. Nelson, Limone C. Collins Jr., Christina Spooner, Brian A. Hemann, Barnett T. Gibbs +14 others
  • 2015
BACKGROUND Although myocarditis/pericarditis (MP) has been identified as an adverse event following smallpox vaccine (SPX), the prospective incidence of this reaction and new onset cardiac symptoms, including possible subclinical injury, has not been prospectively defined. PURPOSE The study's primary objective was to determine the prospective incidence of(More)
Aurora kinases are essential for cell division and are frequently misregulated in human cancers. Based on their potential as cancer therapeutics, a plethora of small molecule Aurora kinase inhibitors have been developed, with a subset having been adopted as tools in cell biology. Here, we fill a gap in the characterization of Aurora kinase inhibitors by(More)