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Overexpression studies have shown that the small heat shock proteins (sHSP) protect the myocardium from ischemia-reperfusion (I/R)-induced damage. However, gene deletion studies are necessary to demonstrate whether sHSPs are required for protection. The genes for alphaB-crystallin (alphaBC) and HSPB2, two sHSPs that are expressed in high levels in the(More)
Recent evidence indicates that sphingolipids are produced by the heart during hypoxic stress and by blood platelets during thrombus formation. It is therefore possible that sphingolipids may influence heart cell function by interacting with G-protein-coupled receptors of the Edg family. In the present study, it was found that sphingosine 1-phosphate(More)
Sphingosine (SPH) is a naturally occurring signaling molecule thought to be responsible for the negative inotropic and cardiotoxic effects of the pro-inflammatory cytokine, TNFα. When subjected to hypoxia and acidosis, Langendorff perfused adult rabbit hearts generate SPH, and isolated adult rat cardiomyocytes released TNFα and SPH into the cell-conditioned(More)
Prod24 DIFFERENCES his article reports the results of an empirical study of the impact of fourth generation languages (4GLs) on system development productivity relative to third generation languages (3GLs). Improving software development productivity has long heen a major objective of the information systems community, and the large number of technological(More)
End-user computing in organizations with different information systems strategies was studied to determine the nature and characteristics of user-developed applications, systems development practices, quality assurance methods, and policies and procedures for end-user development. The findings showed that the information systems strategies of the firms(More)