Robert Kilkuskie

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Although the cancer cell cytoskeleton is a clinically validated target, few new strategies have emerged for selectively targeting cell division by modulating the cytoskeletal structure, particularly ways that could avoid the cardiotoxic and neurotoxic effects of current agents such as taxanes. We address this gap by describing a novel class of(More)
Chemotypes are presented as a way of selecting a handful of nonoverlapping substructures for a molecular structure representing such things as ring systems and formal counterparts of functional groups. By taking positioning into account, chemotypes can be viewed as a priori postulates of the critical substructure of a compound should it become a lead. The(More)
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