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CONTEXT Recent studies have suggested that obese men have lower serum prostate-specific antigen (PSA) concentrations than nonobese men. Because men with higher body mass index (BMI) have greater circulating plasma volumes, lower PSA concentrations among obese men may be due to hemodilution. OBJECTIVE To determine the association between hemodilution and(More)
BACKGROUND Prostate cancer (PC) mortality is much greater for African American than for Caucasian men. To identify patient factors that might account for some of this disparity, men within 6 months of diagnosis were surveyed about health attitudes and behavior. METHODS Using Rapid Identification in the North Carolina Cancer Registry, 207 African American(More)
To study the effect of healthcare access and other characteristics on physician trust among black and white prostate cancer patients. A three-timepoint follow-up telephone survey after cancer diagnosis was conducted. This study analyzed data on 474 patients and their 1,320 interviews over three time periods. Among other subpopulations, black patients who(More)
BACKGROUND Active self-ligating brackets may be more efficient than conventional pre-adjusted brackets. AIMS To determine if self-ligating brackets are more efficient than conventional pre-adjusted brackets when used in a specialist practice setting. METHODS Seven hundred and sixty two patients, consecutively treated with fixed appliances, were(More)
Partnerships between scientists and local communities can increase research capacity and data delivery while improving management effectiveness through enhanced community participation. To encourage such collaboration, this study demonstrates how these partnerships can be formed, drawing on two case studies in coral reef ecosystems in very different social(More)
BACKGROUND Many men (21-52%) are reported to have no cancer on the second, also known as the confirmatory, biopsy (B2) for prostate cancer active surveillance (AS). If these men had a reduced risk of pathologic progression, particularly grade related, the intensity of their follow-up could be decreased. OBJECTIVE To investigate if men with no cancer on B2(More)
BACKGROUND Exposure to metformin, a medication used to treat diabetes, has been associated with improved survival outcomes in various malignancies. However, studies evaluating the association between metformin use and kidney cancer survival outcomes have demonstrated conflicting results. PATIENTS AND METHODS We performed a retrospective review of diabetic(More)
Survival rates in kidney cancer have improved little over time, and diabetes may be an independent risk factor for poor survival in kidney cancer. We sought to determine whether medications with putative anti-neoplastic properties (statins, metformin and non-steroidal anti-inflammatory drugs (NSAIDs)) are associated with survival in diabetics with kidney(More)
We review the published literature regarding the technical feasibility, oncologic outcomes, morbidity, and cost-effectiveness of laparoscopic retroperitoneal lymph node dissection (LRPLND). With proof that it is feasible, several centers have become expert in LRPLND and morbidity appears to be less than that of open RPLND. As the technique improves, it is(More)
PURPOSE We examined prostatectomy pathology, and oncologic and functional outcomes of men progressing from active surveillance to radical prostatectomy. MATERIALS AND METHODS We identified patients on active surveillance treated with radical prostatectomy. We compared patients on active surveillance ultimately treated with radical prostatectomy to age and(More)