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  • Amin Rostami-Hodjegan, Ajmal M Amin, Edgar Pathrose Spencer, Martin S. Lennard, Geoffrey T Tucker, Robert James Flanagan
  • Psychology, Medicine
  • Journal of clinical psychopharmacology
  • 2004 (First Publication: 1 February 2004)
  • The measurement of plasma clozapine concentrations is useful in assessing compliance, optimizing therapy, and minimizing toxicity. We measured plasma clozapine and norclozapine (N-desmethylclozapine)Continue Reading
  • Lewis Couchman, Phillip Edgar Morgan, Edgar Pathrose Spencer, Robert James Flanagan
  • Medicine
  • Therapeutic drug monitoring
  • 2010 (First Publication: 1 August 2010)
  • Therapeutic drug monitoring of plasma clozapine and of its principal plasma metabolite N-desmethylclozapine (norclozapine) (predose or "trough" sample) can help in monitoring adherence, in doseContinue Reading
  • Rodrigo Affonseca Bressan, Kjell Erlandsson, +4 authors Lyn S. Pilowsky
  • Medicine, Psychology
  • The American journal of psychiatry
  • 2003 (First Publication: 1 August 2003)
  • OBJECTIVE Atypical antipsychotic drug treatment is clinically effective with a low risk of extrapyramidal symptoms. Explanations for the mechanism underlying this beneficial therapeutic profile ofContinue Reading
  • Tracey Gous, Lewis Couchman, Jignesh P Patel, Chitongo Paradzai, Roopen Arya, Robert James Flanagan
  • Medicine
  • Therapeutic drug monitoring
  • 2014 (First Publication: 1 October 2014)
  • BACKGROUND Direct oral anticoagulants (DOACs) are prescribed for systemic anticoagulation. Fixed doses are recommended, but dose individualization may be warranted. Functional coagulation assays mayContinue Reading