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Classification of Intrinsically Disordered Regions and Proteins
TLDR
Characterization of unannotated and uncharacterized protein segments is expected to lead to the discovery of novel functions as well as provide important insights into existing biological processes and is likely to shed new light on molecular mechanisms of diseases that are not yet fully understood.
ELM—the database of eukaryotic linear motifs
TLDR
The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances.
A reference map of the human binary protein interactome
TLDR
The utility of HuRI is demonstrated in identifying the specific subcellular roles of protein–protein interactions and in identifying potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases.
The eukaryotic linear motif resource ELM: 10 years and counting
TLDR
The eukaryotic linear motif (ELM) resource is a hub for collecting, classifying and curating information about short linear motifs (SLiMs) and detailed information about motif-mediated interactions has been annotated and made available in standard exchange formats.
Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation.
Interaction Modules Directing Cell Regulation Kim Van Roey,† Bora Uyar,† Robert J. Weatheritt,‡ Holger Dinkel,† Markus Seiler,† Aidan Budd,† Toby J. Gibson,† and Norman E. Davey*,†,§ †Structural and
Attributes of short linear motifs.
TLDR
Analysis of curated instances currently available in the Eukaryotic Linear Motif database suggest that functional SLiMs have higher levels of conservation than their surrounding residues, frequently evolve convergently, preferentially occur in disordered regions and often form a secondary structure when bound to their interaction partner.
ELM: the status of the 2010 eukaryotic linear motif resource
TLDR
The ELM resource at http://elm.eu provides an expanding knowledge base, currently covering 146 known motifs, with annotation that includes >1300 experimentally reported instances, and is an exploratory tool for suggesting new candidates of known linear motifs in proteins of interest.
Drift and conservation of differential exon usage across tissues in primate species
TLDR
The theory that isoform regulation is an important target of evolution in primates is supported by the analysis of transcriptomes of five tissues for six primate species, focusing on exons that are 1:1 orthologous in all six species.
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