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Classification of Intrinsically Disordered Regions and Proteins
1.1. Uncharacterized Protein Segments Are a Source of Functional Novelty Over the past decade, we have observed a massive increase in the amount of information describing protein sequences from aExpand
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A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains
Alternative splicing (AS) generates vast transcriptomic and proteomic complexity. However, which of the myriad of detected AS events provide important biological functions is not well understood.Expand
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ELM—the database of eukaryotic linear motifs
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspectExpand
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The eukaryotic linear motif resource ELM: 10 years and counting
The eukaryotic linear motif (ELM http://elm.eu.org) resource is a hub for collecting, classifying and curating information about short linear motifs (SLiMs). For >10 years, this resource has providedExpand
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Short linear motifs: ubiquitous and functionally diverse protein interaction modules directing cell regulation.
Interaction Modules Directing Cell Regulation Kim Van Roey,† Bora Uyar,† Robert J. Weatheritt,‡ Holger Dinkel,† Markus Seiler,† Aidan Budd,† Toby J. Gibson,† and Norman E. Davey*,†,§ †Structural andExpand
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Attributes of short linear motifs.
Traditionally, protein-protein interactions were thought to be mediated by large, structured domains. However, it has become clear that the interactome comprises a wide range of binding interfacesExpand
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ELM: the status of the 2010 eukaryotic linear motif resource
Linear motifs are short segments of multidomain proteins that provide regulatory functions independently of protein tertiary structure. Much of intracellular signalling passes through proteinExpand
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Drift and conservation of differential exon usage across tissues in primate species
Significance In higher organisms, most genes consist of several disconnected regions (exons), which are combined in various ways to produce several different gene transcripts from the same gene. SuchExpand
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Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop.
Alternative splicing (AS) is a widespread process underlying the generation of transcriptomic and proteomic diversity and is frequently misregulated in human disease. Accordingly, an important goalExpand
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Executive control of spatial attention shifts in the auditory compared to the visual modality
Voluntary orienting of visual spatial attention has been shown to be associated with activation in a distributed network of frontal and parietal brain areas. Neuropsychological data suggest that atExpand
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