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  • Robert J. Mark, Mark A Lovell, William R. Markesbery, Kunitoshi Uchida, Mark P. Mattson
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 1997 (First Publication: 18 November 2002)
  • Peroxidation of membrane lipids results in release of the aldehyde 4-hydroxynonenal (HNE), which is known to conjugate to specific amino acids of proteins and may alter their function. BecauseContinue Reading
  • Robert J. Mark, Zhen Pang, James Geddes, Kunitoshi Uchida, Mark P. Mattson
  • Biology, Medicine
  • The Journal of Neuroscience
  • 1997 (First Publication: 1 February 1997)
  • A deficit in glucose uptake and a deposition of amyloid β-peptide (Aβ) each occur in vulnerable brain regions in Alzheimer’s disease (AD). It is not known whether mechanistic links exist between AβContinue Reading
  • Robert J. Mark, Kenneth Hensley, D Allan Butterfield, Mark P. Mattson
  • Medicine, Biology
  • The Journal of neuroscience : the official…
  • 1995 (First Publication: 1 September 1995)
  • The amyloid beta-peptide (A beta) that accumulates as insoluble plaques in the brain in Alzheimer's disease can be directly neurotoxic and can increase neuronal vulnerability to excitotoxic insults.Continue Reading
  • Aiwu Cheng, Thiruma V Arumugam, +10 authors Mark P. Mattson
  • Medicine, Biology
  • The Journal of Neuroscience
  • 2007 (First Publication: 14 February 2007)
  • The actin-modulating protein Wiskott-Aldrich syndrome protein verprolin homologous-1 (WAVE1) and a novel CNS-specific protein, pancortin, are highly enriched in adult cerebral cortex, but theirContinue Reading
  • Joe E Springer, Robert D. Azbill, Robert J. Mark, James G. Begley, Georg Waeg, Mark P. Mattson
  • Chemistry, Medicine
  • Journal of neurochemistry
  • 1997 (First Publication: 18 November 2002)
  • Traumatic injury to the spinal cord initiates a host of pathophysiological events that are secondary to the initial insult. One such event is the accumulation of free radicals that damage lipids,Continue Reading
  • James F. Kelly, Katsutoshi Furukawa, +5 authors Mark P. Mattson
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1996 (First Publication: 25 June 1996)
  • Cholinergic pathways serve important functions in learning and memory processes, and deficits in cholinergic transmission occur in Alzheimer disease (AD). A subset of muscarinic cholinergic receptorsContinue Reading
    Amyloid beta-peptide (A beta) is deposited as insoluble fibrils in the brain parenchyma and cerebral blood vessels in Alzheimer's disease (AD). In addition to neuronal degeneration, cerebral vascularContinue Reading
  • Jeffrey N Keller, Robert J. Mark, Annadora J. Bruce, Emmanuelle M. Blanc, Mark P. Mattson
  • Medicine, Chemistry
  • Neuroscience
  • 1997 (First Publication: 1 July 1997)
  • Removal of extracellular glutamate at synapses, by specific high-affinity glutamate transporters, is critical to prevent excitotoxic injury to neurons. Oxidative stress has been implicated in theContinue Reading