Robert J. Ross

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PURPOSE Senescent Ccl2(-/-) mice are reported to develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are also found to be associated with AMD. The authors generated Ccl2(-/-)/Cx3cr1(-/-) mice to establish a more characteristic and reproducible AMD model. METHODS Single(More)
a r t i c l e i n f o a b s t r a c t We present a detailed semantics for linguistic spatial expressions supportive of computational processing that draws substantially on the principles and tools of ontological engineering and formal ontology. We cover language concerned with space, actions in space and spatial relationships and develop an ontological(More)
Nature’s engineering of wood through genetics, stand conditions, and environment creates wide variability in wood as a material, which in turn introduces difficulties in wood processing and utilization. Manufacturers sometimes find it difficult to consistently process wood into quality products because of its wide range of properties. The primary objective(More)
The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated dimension of biology. The PIWI-piRNA pathway has been commonly perceived as germline-specific, even though the somatic function of PIWI proteins was documented when they were first discovered. Recent studies have begun to re-explore this pathway in somatic cells in(More)
This study investigates age-related macular degeneration (AMD) genetic risk factors through identification of a functional single-nucleotide polymorphism (SNP) and its disease association. We chose ERCC6 because of its roles in the aging process, DNA repair, and ocular degeneration from the gene disruption. Bioinformatics indicated a putative(More)
BACKGROUND/AIMS Senescent Ccl2-/- mice develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are associated with AMD. METHODS We generated Ccl2-/-/Cx3cr1-/- [double-knockout (DKO)] mice and evaluated the eyes using fundoscopy routine histology, immunochemistry,(More)
Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness in the USA. Although the treatment of AMD has evolved to include laser photocoagulation, photodynamic therapy, surgical macular translocation and antiangiogenesis agents, treatment options for advanced AMD are limited. Furthermore, the dry form of AMD, albeit less(More)
For AOP (Agent Oriented Programming) to become a mature discipline, lessons must be learned from practical language implementations. We present AF-APL (AgentFactory Agent Programming Language) as an Agent Oriented Programming Language that has matured with continued revisions and implementations, resulting in a language which, although based on the more(More)
This paper describes a revision to the design of Agent-Oriented Programming (AOP) that introduces the concept of a role. The proposed AOP framework introduces the notion of a role template and describes how these templates can be used to engender code reuse. We then use this framework to extend the ALPHA programming language and illustrate the use of this(More)
This paper describes an experiment to evaluate the impact of idioms on Statistical Machine Translation (SMT) process using the language pair English/BrazilianPortuguese. Our results show that on sentences containing idioms a standard SMT system achieves about half the BLEU score of the same system when applied to sentences that do not contain idioms. We(More)