Robert J Luallen

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Microsporidia comprise a highly diverged phylum of intracellular, eukaryotic pathogens, with some species able to cause life-threatening illnesses in immunocompromised patients. To better understand microsporidian infection in animals, we study infection of the genetic model organism Caenorhabditis elegans and a species of microsporidia, Nematocida parisii,(More)
The growth of pathogens is dictated by their interactions with the host environment1. Obligate intracellular pathogens undergo several cellular decisions as they progress through their life cycles inside host cells2. We have studied this process for microsporidian species in the genus Nematocida as they grew and developed inside their co-evolved animal(More)
Microbial pathogens often establish infection within particular niches of their host for replication. Determining how infection occurs preferentially in specific host tissues is a key aspect of understanding host-microbe interactions. Here, we describe the discovery of a natural microsporidian parasite of the nematode Caenorhabditis elegans that displays a(More)
Microsporidia are fungi-related intracellular pathogens that may infect virtually all animals, but are poorly understood. The nematode Caenorhabditis elegans has recently become a model host for studying microsporidia through the identification of its natural microsporidian pathogen Nematocida parisii. However, it was unclear how widespread and diverse(More)
a Institut de Biologie de l’Ecole Normale Supérieure, CNRS, Inserm, ENS, PSL Research University, 75005 Paris, France b School of Life Sciences, East China Normal University, 200062 Shanghai, China c Ultrapole, Institute Pasteur, 75015 Paris, France. d Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San(More)
e-mail: M pathogens can invade their hosts through a variety of routes, but one path is to sneak in through an open wound in the external body surface. To stave off these microbial invaders, hosts can sense a breach in the epidermal barrier and rapidly upregulate antimicrobial defenses1,2. The nematode Caenorhabditis elegans responds to(More)
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