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We have characterized a flat cellular variant of HTLV-1 Tax-transformed rat fibroblasts, 5R, which is unresponsive to all tested NF-kappaB activating stimuli, and we report here its genetic complementation. The recovered full-length cDNA encodes a 48 kDa protein, NEMO (NF-kappaB Essential MOdulator), which contains a putative leucine zipper motif. This(More)
active NF-␬B is released and translocated to the nucleus as a result of the proteolytic degradation of I␬B proteins. Phosphorylation of I␬B␣ on Ser-32 and Ser-36 targets the molecule for degradation by the ubiquitin-26S pro-teasome pathway. While the processes leading to the degradation of the I␬B proteins are relatively well under-de l'Expression Gé nique(More)
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