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Engineered genetic systems are commonly unstable; if propagated, they evolve to reverse or modify engineered elements because the elements impair fitness. A goal of synthetic biology is thus to anticipate and avoid detrimental engineering, but little is yet known about which types of elements cause problems in different contexts. In prior work, 30% of the(More)
which identifies and prioritizes research and development (R&D) needs with the goal of giving decision makers at all levels of government more accurate and timely information when biological incidents threaten health. Such incidents—whether the result of natural evolutionary causes, accidental releases or exposures, or malevolent activities—have the(More)
Flavone acetic acid (FAA) is an investigational drug that augments natural killer activity, induces the genes for a-and 7-interferon (IFN) and tumor necrosis factor a, and synergizes with recombinant interleukin 2 for the successful treatment of murine renai cancer. However, in most clinical studies of FAA only minimal immunomodulatory effects have been(More)
ACKNOWLEDGMENTS I would first like to thank my family for all their encouragement and reality checks throughout this process. Especially to my dad for trying desperately to understand what it is that I actually do. Without him, I would never have made it this far. To my fiancée, Victoria, for always supporting me and allowing me to do research. The best is(More)
  • R Bull
  • 2001
Primary tasks for clinical directors are to disseminate information to colleagues, provide feedback to senior professional managers, and to play key roles in strategic planning and resource allocation in health services. These tasks are seen to reduce barriers between clinicians and management. The application of clinical directorates across healthcare(More)
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