Robert I. Taber

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Neuropeptide Y (NPY) is a powerful stimulant of food intake and is proposed to activate a hypothalamic 'feeding' receptor distinct from previously cloned Y-type receptors. This receptor was first suggested to explain a feeding response to NPY and related peptides, including NPY2-36, that differed from their activities at the Y1 receptor. Here we report the(More)
The ability of p-chlorophenylalanine (PCPA), an inhibitor of serotonin (5HT) biosynthesis to antagonize the antinociceptive effects of three classes of analgesics: opiates agonist (morphine), opiate agonist-antagonist (pentazocine) and non-steroid anti-inflammatory (aspirin and clonixin) were evaluated using the rat yeast paw test. The analgesic effect of(More)
Sch 12679, N-methyl-l-phenyl-7,8-dimethoxy-2,3,4,5-tetrahydro-3-benzazepine maleate, is active in a broad spectrum of laboratory models of aggressive behavior without producing any signs of neurologic impairment up to lethal doses. Sch 12679 is an effective inhibitor of isolation-induced aggression in mice, muricide and septal lesion-induced aggression in(More)
1. Cocaine did not antagonize the tyramine-induced contractile response of the isolated rat vas deferens at the same concentrations which markedly potentiated the contractile response to noradrenaline.2. Imipramine and amitriptyline non-competitively antagonized the contractile response to tyramine but did not potentiate noradrenaline. Desmethylimipramine(More)