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Journals and Conferences
This is a description of an alternative type of vitrectomy instrument system which is characterized by specific advantages for mobilizing and removing sluggish intracapsular lens material, blood, debris, or plasmoid liquid pooled or sedimented at the posterior pole; and modular one-surgeon units adaptable to contemporary vitrectomy devices and techniques… (More)
We describe a novel series of potent inhibitors of human beta-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5A crystal structure of inhibitor 32 bound to BACE is provided.
alpha-Piperidine-beta-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. The investigation of the beta-sulfones subsequently led to the discovery of hitherto unknown alpha-sulfone hydroxamates that are superior to the corresponding beta-sulfones in potency for target… (More)
We have discovered a new series of potent MMP Inhibitors that are selective for MMP-13 over MMP-1 incorporating a gamma-sulfone thiol.
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold selectivity for MMP-13 versus MMP-2 and -8.
Continued experience confirms the suitability of electrovitreotomy for dividing pathogenically taut proliferative and non-proliferative vitreous forms with a minimum of bleeding, and an inability to cut vitreous of ordinary consistency and tension. It differs directly with electrovitrectomy in these regards. To use effectively with a minimum of… (More)
Fraulein E~JEA ST~UFE~rE:~R~, med.-techn. Assistentln, sei auch an dieser Stelle flit ihre verst/~ndnisvolle Mitarbeit gedankt. Literatur. A~L~-, E. V., N. W. B ~ and E. A. IIn~Es: Peripheral vascular diseases. Philadelphia 1947. Braes, g., A. S. DOV~LAS and R. G. McFx~nA~E: J. of Physiol. 119, 89 (1953). BECK, H. E., u. 1~o GRoss: D~sch. med. Wschr. 1956,… (More)