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Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of acute vascular rejection is not yet known; however, a variety of observations suggest that the humoral immune response of the recipient against the donor may be involved in the pathogenesis of this process. Using a pig-to-baboon heterotopic(More)
Immunoglobulins regulate the complement system by activating complement on foreign surfaces and diverting reactive complement proteins away from autologous cell surfaces. Based on this model, we explored the ability of Ig to balance complement activation versus control in a pig-to-primate cardiac xenotransplantation model in which the binding of(More)
BACKGROUND There are multiple models of mental illness that inform professional and lay understanding. Few studies have formally investigated psychiatrists' attitudes. We aimed to measure how a group of trainee psychiatrists understand familiar mental illnesses in terms of propositions drawn from different models. METHOD We used a questionnaire study of a(More)
Longer wait times for deceased donor kidney transplant have prompted newer initiatives to expedite the process. Reuse of a previously transplanted kidney might be appropriate in certain circumstances. However, one must also consider the unique issues that may arise after such transplants. We describe our experience in one such case where the donor kidney(More)
This edition of the Schizophrenia Bulletin brings together 7 papers first presented at the conference ''Phenomenol-ogy and Psychiatry for the 21st century'' held at the Institute of Psychiatry, London, in September 2005. The conference initially aimed to redress an imbalance in training (both clinical and research) yet ended up attracting speakers and(More)
there have been signs of a renais-Recently there have been signs of a renaissance of interest in the role of the social sance of interest in the role of the social environment in causing schizophrenia and environment in causing schizophrenia and other psychoses (van Os, 2004). This other psychoses (van Os, 2004). This resurgence is fuelled by both a(More)
The weight of history is upon me, both physically and metaphysically. I am both very grateful and extremely humble on receipt of this magnificent chain of office, and of the responsibilities it implies. I shall make every effort to maintain the high standards set by all my predecessors. In that regard I would particularly want to congratulate Bob Stout on a(More)
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