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Increasingly shorter product life cycles impel ÿrms to design, develop, and market more products in less time than ever before. Overlapping of design and development stages is commonly regarded as the most promising strategy to reduce product development times. However, overlapping typically requires additional resources and can be costly. Our research(More)
SUMMARY The in vivo localization of radiolabeled heterospecific antibody to carcinoembryonic antigen (CEA) was inves tigated in a human colonie tumor-hamster host model. With the paired-labeled antibody technique, a significant and specific accumulation of goat anti-CEA immunoglobu-lin G (IgG) was observed in small tumors (<5.0 g) l day after injection. The(More)
The appearance of anti-carcinoembryonic antigen (CEA) activity in the sera of hamsters bearing i.m. heterografts of GW-39, a CEA-producing colonic tumor of human origin, was demonstrated in radioimmunoassay using radioiodinated CEA purified from GW-39. Column chromatography, sucrose gradient ultracentrifugation, and radioimmunoelectrophoresis of pooled sera(More)
A triple-bridge, indirect, immunoperoxidase method for detecting and localizing carcinoembryonic antigen (CEA) in tissue sections is described. By this technique, a cell-surface localization of CEA in colonic carcinoma and ovarian mucinous cystadenocarcinoma cells could be visualized. In the case of the colonic cancer, both the tumor from the descending(More)
This paper describes the Semiconductor Wafer Representation (SWR) for representing and manipulating wafer state during process and device simulation. The goal of the SWR is to provide an object-oriented interface to a collection of functions designed for developing and integrating Technology CAD (TCAD) applications. By providing functions which can be(More)
Deoxygenation of erythrocytes from sickle cell anemia (SCA) patients alters membrane phospholipid distribution with increased exposure of phosphatidylethanolamine (PE) and phosphatidylserine (PS) on the outer leaflet. This study investigated whether altered membrane phospholipid exposure on sickle erythrocytes results in complement activation. In vitro(More)
The binding of (1)-[3H]vesamicol was characterized in several subcellular fractions and brain regions of the rat. Binding to a lysed P2 fraction from the rat cerebral cortex reached equilibrium within 4 min at 37 degrees C and was reversible (dissociation half-time 4.9 min). At least two binding affinities were found in P2 fractions from the cerebral cortex(More)
This paper proposes operational frameworks for structuring product development processes. The primary objective of this research is to develop procedures to minimize iterations during the development process which adversely a€ect development time and costs. Several procedures are introduced to restructure the development process. The computation of the(More)
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