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OBJECTIVE To describe the time sequence of changes in fetal monitoring variables in intrauterine growth restriction and to correlate these findings with fetal outcome at delivery. METHODS This was a prospective longitudinal observational multicenter study on 110 singleton pregnancies with growth-restricted fetuses after 24 weeks of gestation. Short-term(More)
OBJECTIVE To review the literature about the effect of normal pregnancy on cardiac output, with special attention to study design, measurement technique, position of the subject, and parity. DATA SOURCES For studies from the period 1955-1987, we examined Cumulated Index Medicus (National Library of Medicine Cataloging in Publication. Chicago: American(More)
OBJECTIVE To investigate whether pathological changes in the umbilical artery (UA), ductus venosus (DV) and short-term fetal heart variation are related to perinatal outcome in severe, early intrauterine growth restriction (IUGR). METHODS This multicenter, prospective, longitudinal, observational study was carried out in the Departments of Fetal Medicine(More)
In the present study, we compared brain development and metabolism of small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) infants using proton magnetic resonance spectroscopy ((1)H-MRS). We tested the hypothesis that intrauterine growth retardation caused by placental insufficiency is associated with changes in cerebral metabolism and(More)
OBJECTIVES To examine changes with time in the fetal renal circulation by Doppler sonography in the severely growth-restricted preterm fetus during the period of gradual deterioration prior to delivery, and to examine the relationship between Doppler measurements, amniotic fluid index, birth weight and fetal condition at birth. METHODS This was a(More)
OBJECTIVE To investigate the variation in the dimensions of the fetal renal pelvis in relation to the degree of bladder filling in fetuses with mild pyelectasis. METHODS Eighteen third-trimester pregnant women with mild uni- or bilateral fetal pyelectasis, defined as an anteroposterior (A-P) diameter of the renal pelvis between 5 and 10 mm, were recruited(More)
BACKGROUND Severe intrauterine hypoxia-ischemia and acidemia may lead to a disturbed neurodevelopment. OBJECTIVES To study the effects of acidemia at birth on neurodevelopment in preterm and full-term neonates. SUBJECTS AND METHODS Short- and long-term outcome were studied retrospectively in 44 inborn preterms and 95 full-terms with severe acidemia at(More)
OBJECTIVE To determine the long-term prognosis of antenatally detected renal tract anomalies in order to optimize parental counseling. METHODS This was a follow-up study of all renal tract abnormalities detected antenatally in a Level 3 ultrasound department between 1986 and 2001. Follow-up data (median age, 8 years) were retrieved from the records of the(More)
OBJECTIVE To establish reference curves for size and volume of the fetal kidney, renal pelvis and adrenal gland, as measured using ultrasound from the 15(th) week of gestation. METHODS This was a prospective, longitudinal study of 96 fetuses in low-risk singleton pregnancies, in which we performed serial ultrasound examinations at 4-week intervals. The(More)
Maternal betamethasone administration causes a transient but considerable reduction in fetal body and breathing movements and in fetal heart rate variation. The aim of the present prospective study was to investigate whether there is evidence of circulatory changes in fetal, placental or uterine arteries, consistent with hypoxemia. Eighteen women at risk(More)