Robert H. Mitchell

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BACKGROUND Syntaxins 1 through 4 are SNAP receptor (SNARE) proteins that mediate vesicular trafficking to the plasma membrane. In retina, syntaxins 1 and 3 are expressed at conventional and ribbon synapses, respectively, suggesting that synaptic trafficking functions differ among syntaxin isoforms. To better understand syntaxins in synaptic signaling and(More)
Growth factor over-production by responsive cells might contribute to their autonomous proliferation as well as their acquisition of a transformed phenotype in culture. Basic fibroblast growth factor (bFGF) has been shown to induce transient changes in cell behavior that resemble those encountered in transformed cells. In addition, several types of human(More)
Leukemia inhibitory factor (LIF) belongs to the interleukin-6 cytokine family, all members of which signal through the common gp130 receptor. Neurotrophic members of this cytokine family are known to arrest photoreceptor maturation and are likely to regulate maturation of other retinal neurons as well. We have used transgenic mice that constitutively(More)
Process capability indices have been popular for over 20 years, since Joseph Juran 12 popularized the Capability Ratio (Cr) in his Quality Control Handbook. Eagerness to establish a single index to measure process capability has resulted in the proliferation of indices: " Generalized " Cp/Cpk. Abuse of these indices is well documented (Gunter) 8. Though(More)
The views expressed in this thesis are those of the author and do not reflect the official policy or position of the United States Air Force, Department of Defense, or the United States Government. Abstract The purpose of this research was to examine the potential for applying the concept of real options to the DoD acquisition system. The key premise of(More)
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