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A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.

• Shannon L Winski, Robert H J Hargreaves, John L Butler, David D. Ross
• Clinical cancer research : an official journal of…
• 1998

NAD(P)H:quinone oxidoreductase (NQO1; DT-diaphorase) is elevated in certain tumors, such as non-small cell lung cancer (NSCLC). Compounds such as mitomycin C and streptonigrin are efficiently… (More)

Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast…

• Howard D. Beall, Anne Marie Murphy, David Siegel, Robert H J Hargreaves, John K. Butler, David D. Ross
• Molecular pharmacology
• 1995

Bioreductive antitumor quinones require reductive metabolism to produce their cytotoxic effects. A series of these compounds was screened for relative rates of reduction by the two-electron… (More)

Mechanisms of action of quinone-containing alkylating agents: DNA alkylation by aziridinylquinones.

• Robert H J Hargreaves, Judith A. Hartley, John K. Butler
• Frontiers in bioscience : a journal and virtual…
• 2000

Aziridinyl quinones can be activated by cellular reductases eg. DT-diaphorase and cytochrome P450 reductase to form highly reactive DNA alkylating agents. The mechanisms by which this activation and… (More)

Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.

• Shannon L Winski, Elizabeth G. Swann, +4 authors David D. Ross
• Biochemical pharmacology
• 2001

To investigate the importance of NAD(P)H:quinone oxidoreductase 1 (or DT-diaphorase; NQO1) in the bioactivation of antitumor quinones, we established a series of stably transfected cell lines derived… (More)

High-resolution absorption cross sections of C 2 H 6 at elevated temperatures

• Robert H J Hargreaves, Eric Buzan, Michael Dulick, Peter F. Bernath
• 2015

Infrared absorption cross sections near 3.3 μm have been obtained for ethane, C2H6. These were acquired at elevated temperatures (up to 773 K) using a Fourier transform infrared spectrometer and tube… (More)

Preclinical evaluation of the pharmacodynamic properties of 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone.

• Timothy H. Ward, Sarah J. Danson, +6 authors John Butler
• Clinical cancer research : an official journal of…
• 2005

PURPOSE The purpose of our study was to investigate the cellular accumulation, DNA cross-linking ability, and cellular toxicity of RH1 (2,5-diaziridinyl-3-[hydroxymethyl[-6-methyl-1,4-benzoquinone),… (More)

Cross-linking and sequence-specific alkylation of DNA by aziridinylquinones. 3. Effects of alkyl substituents.

• Robert H J Hargreaves, Caroline O'hare, John A. Hartley, David D. Ross, John K. Butler
• Journal of medicinal chemistry
• 1999

The cytotoxicities and DNA cross-linking abilities of several alkyl-substituted diaziridinylquinones have been investigated. The cytotoxicities were determined in DT-diaphorase-rich (H460 and HT29)… (More)

Cross-linking and sequence specific alkylation of DNA BY aziridinylquinones. 1. Quinone methides.

• Stephen P Mayalarp, Robert H J Hargreaves, John K. Butler, Caroline O'hare, John A. Hartley
• Journal of medicinal chemistry
• 1996

The cytotoxicities and DNA cross-linking abilities of 16 1,4-benzoquinones have been investigated. All of the alkylmonoaziridinyl-1,4-benzoquinones were able to interstrand crosslink DNA after… (More)

Cross-linking and sequence specific alkylation of DNA by aziridinyl quinones. 2. Structure requirements for sequence selectivity.

• Robert H J Hargreaves, Stephen P Mayalarp, John K. Butler, Steven McAdam, Caroline O'hare, John A. Hartley
• Journal of medicinal chemistry
• 1997

The cytotoxicities and DNA sequence selectivity for guanine-N7 alkylation of 22 mono- and disubstituted 2,5-diaziridinyl-1,4-benzoquinones have been investigated. Several quinones produced patterns… (More)

The abnormal cytotoxicities of 2,5-diaziridinyl-1,4-benzoquinone-3-phenyl esters.

• Angela Maria Di Francesco, Robert H J Hargreaves, +4 authors John K. Butler
• Anti-cancer drug design
• 2000

Several derivatives of 2,5-diaziridinyl-3-phenyl-1,4-benzoquinone have been synthesized and their cytotoxicities in six different human cancer cell lines (H460, H596, HT29, BE, K562 and A2780) have… (More)

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