Learn More
The neurofibromatoses are a diverse group of genetic conditions that share a predisposition to the development of tumors of the nerve sheath. Schwannomatosis is a recently recognized third major form of neurofibromatosis (NF) that causes multiple schwannomas without vestibular tumors diagnostic of NF2. Patients with schwannomatosis represent 2.4 to 5% of(More)
MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function(More)
The Caenorhabditis elegans locus lin-15 negatively regulates an intercellular signaling process that induces formation of the hermaphrodite vulva. The lin-15 locus controls two separate genetic activities. Mutants that lack both activities have multiple, ectopic pseudo-vulvae resulting from the overproduction of vulval cells, whereas mutants defective in(More)
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease that is inherited as an autosomal dominant trait in approximately 10% of cases. Recently we and others identified several single-base mutations in the Cu/Zn superoxide dismutase (SOD1) gene in patients with familial ALS (FALS). Using single-strand conformational polymorphism, we(More)
I never expected to spend most of my life studying worms. However, when it came time for me to choose an area for my postdoctoral research, I was intrigued both with the problems of neurobiology and with the approaches of genetics. Having heard that a new " genetic organism " with a remarkably simple nervous system was being explored by Sydney Brenner – the(More)
Clustering and interrelationships of common and easily identifiable risk factors in 951 children (ages 6-19) from the Cincinnati Lipid Research Clinic's Princeton School of District Study were assessed. Several patterns of partial correlation coeffieients appeared after multiple regression analysis with adjustment for age, sex, Quetelet index, and race.(More)
To provide population data on levels of plasma cholesterol, triglyceride, and high- and low-density lipoprotein-cholesterol (HDL-C and LDL-C) in black adults, 627 black adults, aged 20 to 59 years, 206 men and 421 women, were studied in the Cincinnati Lipid Research Clinic's Princeton School Study. Comparisons were made with 2,493 white adults, aged 20 to(More)
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. SUMMARY The C. elegans HIF-1 proline hydroxylase EGL-9 functions as an O 2(More)