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The Caenorhabditis elegans locus lin-15 negatively regulates an intercellular signaling process that induces formation of the hermaphrodite vulva. The lin-15 locus controls two separate genetic activities. Mutants that lack both activities have multiple, ectopic pseudo-vulvae resulting from the overproduction of vulval cells, whereas mutants defective in(More)
MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function(More)
The neurofibromatoses are a diverse group of genetic conditions that share a predisposition to the development of tumors of the nerve sheath. Schwannomatosis is a recently recognized third major form of neurofibromatosis (NF) that causes multiple schwannomas without vestibular tumors diagnostic of NF2. Patients with schwannomatosis represent 2.4 to 5% of(More)
Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease that is inherited as an autosomal dominant trait in approximately 10% of cases. Recently we and others identified several single-base mutations in the Cu/Zn superoxide dismutase (SOD1) gene in patients with familial ALS (FALS). Using single-strand conformational polymorphism, we(More)
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. SUMMARY The C. elegans HIF-1 proline hydroxylase EGL-9 functions as an O 2(More)
I never expected to spend most of my life studying worms. However, when it came time for me to choose an area for my postdoctoral research, I was intrigued both with the problems of neurobiology and with the approaches of genetics. Having heard that a new " genetic organism " with a remarkably simple nervous system was being explored by Sydney Brenner – the(More)
The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a(More)
1983). The engulfment defect of ced-1 delays the degra-Boston, Massachusetts 02115 dation of dead cells and provided a genetic background 2 Howard Hughes Medical Institute that allowed the ready visualization of accumulated un-Department of Biology engulfed cell corpses. Massachusetts Institute of Technology The first ced-3 mutation was isolated because it(More)
Vandalism and Programmed Threats, Adapso (1989). He has contributed chapters to many other books on computer security and professional ethics, and has spoken internationally at conferences, symposia, and colloquia on these issues. Dr. Spaord is a member of the Association for Computing Machinery (ACM). He is chair of the ACM Self-Assessment Committee, and(More)