Robert H. Hall

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Isogenic mutant strains of V. cholerae O1 lacking elements of a genetic regulon controlled by toxR and implicated in virulence were tested in volunteers. A deletion mutation in ctxA, the gene encoding the A subunit of cholera toxin, markedly attenuated disease symptoms without affecting intestinal colonization. Deletion of toxR, the gene encoding the(More)
Important biomedical information is often recorded, published or archived in unstructured and semi-structured textual form. Artificial intelligence and knowledge discovery techniques may be applied to large volumes of such data to identify and extract useful metadata, not only for providing access to these documents, but also for conducting analyses and(More)
b W e were disappointed to read the Journal of Clinical Microbiology (JCM) editor in chief's recent editorial " An Obituary for the Case Report in Journal of Clinical Microbiology " (1). Despite the steady increase in the number of case reports published , the editorial board reportedly decided that case reports seldom add truly significant information to(More)
The 50-year commemoration of S.N. De's seminal 1959 publication in Nature provides an opportunity to reflect on scientific discovery, recognition, and public health. De's paper marked the first major conceptual advance in cholera research since 1884, when Robert Koch definitively identified Der Kommabazillus as the aetiological agent of cholera.(More)
Escherichia coli O157:H7 and Salmonella are among the most important foodborne pathogens that cause millions cases of infections and hundreds deaths each year in the United States. Beef and poultry products are frequently recognized transmission media for these two organisms. Rapid detection and isolation methods applied to beef or chicken products are(More)
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