Robert Guttman

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Alzheimer disease (AD) takes a heavy economic, social, physical, and psychological toll on patients, families, and society. Because of the increasing life expectancy in the United States, AD is expected to afflict approximately 14 million people within the next few decades. There is currently no cure, only interventions that can temporarily ameliorate the(More)
Despite year-to-year increases in R & D budgets, the number of successful NCEs (new chemical entities) has continued to decline. Drug companies are looking into new ways to make research processes more efficient, to manage information better, and to improve collaboration among research groups. This shift from an artisan approach to an organized, streamlined(More)
OBJECTIVE To examine issues related to the use of restraints on nursing home patients, including regulations and guidelines, risks and benefits of restraint use, system problems, and measures to reduce restraint use, to determine when the use of restraints results in clinically desirable outcomes. METHODS Sources of information included a review of(More)
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