Robert Gillespie

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Methionyl-tRNA synthetase of Trypanosoma brucei (TbMetRS) is an important target in the development of new antitrypanosomal drugs. The enzyme is essential, highly flexible and displaying a large degree of changes in protein domains and binding pockets in the presence of substrate, product and inhibitors. Targeting this protein will benefit from a profound(More)
Results of laboratory tests for kidney stone risk factors are reported based on adult reference ranges and are not readily interpretable in children. We have developed a solution which converts laboratory output to appropriate pediatric patient-adjusted relative units, compares results using age-specific reference ranges, and flags out-of-range values. The(More)
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