Robert Gillespie

Pat Monaghan4
Melissa Bateson4
Ben O. Brilot2
4Pat Monaghan
4Melissa Bateson
2Ben O. Brilot
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Adverse experiences in early life can exert powerful delayed effects on adult survival and health. Telomere attrition is a potentially important mechanism in such effects. One source of early-life adversity is the stress caused by competitive disadvantage. Although previous avian experiments suggest that competitive disadvantage may accelerate telomere(More)
Early-life adversity is associated with poorer health and survival in adulthood in humans and other animals. One pathway by which early-life environmental stressors could affect the adult phenotype is via effects on telomere dynamics. Several studies have shown that early-life adversity is associated with relatively short telomeres, but these are often(More)
Animals in a poor biological state face reduced life expectancy, and as a consequence should make decisions that prioritize immediate survival and reproduction over long-term benefits. We tested the prediction that if, as has been suggested, developmental telomere attrition is a biomarker of state and future life expectancy, then individuals who have(More)
  • John Paul Wanner, Roopashree Subbaiah, Yelenna Skomorovska-Prokvolit, Yousef Shishani, Eric Boilard, Sujatha Mohan +3 others
  • 2013
INTRODUCTION The development of effective treatments for osteoarthritis (OA) has been hampered by a poor understanding of OA at the cellular and molecular levels. Emerging as a disease of the 'whole joint', the importance of the biochemical contribution of various tissues, including synovium, bone and articular cartilage, has become increasingly(More)
Results of laboratory tests for kidney stone risk factors are reported based on adult reference ranges and are not readily interpretable in children. We have developed a solution which converts laboratory output to appropriate pediatric patient-adjusted relative units, compares results using age-specific reference ranges, and flags out-of-range values. The(More)
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