Gerd-Jörg Rauch6
Silke Geiger-Rudolph3
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Hair cells have highly organized bundles of apical projections, or stereocilia, that are deflected by sound and movement. Displacement of stereocilia stretches linkages at the tips of stereocilia that are thought to gate mechanosensory channels. To identify the molecular machinery that mediates mechanotransduction in hair cells, zebrafish mutants were(More)
  • Jeong-Soo Lee, Sophia von der Hardt, Melissa A. Rusch, Sally E. Stringer, Heather L. Stickney, William S. Talbot +5 others
  • 2004
Retinal ganglion cell (RGC) axons are topographically ordered in the optic tract according to their retinal origin. In zebrafish dackel (dak) and boxer (box) mutants, some dorsal RGC axons missort in the optic tract but innervate the tectum topographically. Molecular cloning reveals that dak and box encode ext2 and extl3, glycosyltransferases implicated in(More)
The Tübingen large-scale zebrafish genetic screen completed in 1996 identified a set of five genes required for orderly somite segmentation. Four of them have been molecularly identified and three were found to code for components of the Notch pathway, which are required for the coordinated oscillation of gene expression, known as the segmentation clock, in(More)
In this paper we i n troduce a formal approach for the speciication of safety-critical embedded systems. The speciication formalisms Z and statecharts are integrated under a suitable structural model. The combined approach uses the advantages of the formalisms while avoiding their disadvantages. The diierent formalisms yield diierent, compatible views on(More)
N-cadherin (Ncad) is a classical cadherin that is implicated in several aspects of vertebrate embryonic development, including somitogenesis, heart morphogenesis, neural tube formation and establishment of left-right asymmetry. However, genetic in vivo analyses of its role during neural development have been rather limited. We report the isolation and(More)
  • Susana S. Lopes, Xueyan Yang, Jeanette Müller, Thomas J. Carney, Anthony R. McAdow, Gerd-Jörg Rauch +8 others
  • 2008
A fundamental problem in developmental biology concerns how multipotent precursors choose specific fates. Neural crest cells (NCCs) are multipotent, yet the mechanisms driving specific fate choices remain incompletely understood. Sox10 is required for specification of neural cells and melanocytes from NCCs. Like sox10 mutants, zebrafish shady mutants lack(More)
BACKGROUND Large-scale mutagenesis screens in the zebrafish employing the mutagen ENU have isolated several hundred mutant loci that represent putative developmental control genes. In order to realize the potential of such screens, systematic genetic mapping of the mutations is necessary. Here we report on a large-scale effort to map the mutations generated(More)
  • Marco J Koudijs, Marjo J. den Broeder, Astrid Keijser, Erno Wienholds, Saskia Houwing, Ellen M. H. C. van Rooijen +2 others
  • 2005
Proliferation is one of the basic processes that control embryogenesis. To identify factors involved in the regulation of proliferation, we performed a zebrafish genetic screen in which we used proliferating cell nuclear antigen (PCNA) expression as a readout. Two mutants, hu418B and hu540A, show increased PCNA expression. Morphologically both mutants(More)
In this paper we present an algebraic approach to statecharts as they are used in the Statemate tool in the style of "Petri-Nets are Monoids" for place-transition nets developed by Meseguer and Montanari. We apply the framework of high-level-replacement systems, a categorical generalization of graph transformation systems, in order to deene union as(More)
  • Benjamin D. Weger, Meltem Sahinbas, Georg W. Otto, Philipp Mracek, Olivier Armant, Dirk Dolle +6 others
  • 2011
Most organisms possess circadian clocks that are able to anticipate the day/night cycle and are reset or "entrained" by the ambient light. In the zebrafish, many organs and even cultured cell lines are directly light responsive, allowing for direct entrainment of the clock by light. Here, we have characterized light induced gene transcription in the(More)