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Osteoporosis and other diseases of bone loss are a major public health problem. Here it is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents. This effect was associated with increased expression of the bone morphogenetic protein-2 (BMP-2) gene in bone cells. Lovastatin and(More)
Pre-exercise body temperature varies throughout the day due to its circadian rhythm. This study aimed to compared responses to sustained exercise in the morning and in evening. Rectal temperature was measured pre-exercise and throughout a 60 min test on a cycle ergometer against a fixed frictional resistance in seven males (aged 19-24 years). The subjects(More)
Computer games were modified to encourage respiratory effort by two groups of patients with Duchenne muscular dystrophy. One group trained during the first six months of the study, the other during the second six months. Inspiratory effort was increased by their having to breathe through a mask to both start and continue the games. Pulmonary function tests(More)
Metallic wear particles were prepared from orthopaedic cobalt-chrome alloy by milling in medium supplemented with 20% foetal calf serum to maintain particle dispersion. The size distribution of particles was determined by sedimentation and centrifugation and particle concentration was assessed using light extinction. Monolayers of mouse peritoneal(More)
A clinical, radiological and histopathological study of femoral heads from 125 patients with fracture of the neck of the femur and from 30 cadavers was carried out to identify various risk factors. The findings showed that the Singh index was unreliable as a radiological indicator of the bone content of the femoral heads; that the bone content of the(More)
Batches of urethral catheters associated with stricture formation during clinical usage were found to be amongst those causing marked acute and chronic inflammation after subcutaneous implantation in rats. The degree of inflammation did not correlate with the surface roughness of catheters assessed by scanning electron microscopy, but showed an excellent(More)
The radiographic features of acromesomelic dysplasia are presented, along with a summary of pertinent clinical features. They are thought to allow a diagnosis in affected individuals over six months of age. Since the condition has an autosomal recessive mode of genetic transmission and results in extremely short stature, the establishment of the diagnosis(More)
Human performance generally varies in phase with the circadian curve in body temperature. This relationship between performance and core body temperature may be disrupted when exercise causes a pronounced rise in body temperature. In this study the authors compared responses to exercise in the morning and in the evening when pre-exercise body temperature(More)
Serial coagulation studies were obtained in 25 patients treated with intracoronary streptokinase infusion for myocardial infarction (23 patients) or coronary insufficiency (two patients) to determine the frequency of systemic fibrinolytic activity. Clotting studies were obtained before and after infusion and at 4-hour intervals until normalization.(More)