Robert G Eason

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Incorporation of strain-specific synthetic DNA tags into yeast Saccharomyces cerevisiae gene-deletion strains has enabled identification of gene functions by massively parallel growth rate analysis. However, it is important to confirm the sequences of these tags, because mutations introduced during construction could lead to significant errors in(More)
The electrical method of eye movement recording (EOG) was used to study the reactions of the eyes when subjects attempted to fixate as quickly as possible on light stimuli appearing at various points along the horizontal plane. Each eye was recorded separately, allowing an assessment of the degree of independence of the eyes when reacting in this way. In(More)
This is the first comprehensive profile of cystic fibrosis transmembrane conductance regulator (CFTR) mutations and their corresponding haplotypes in the Iranian population. All of the 27 CFTR exons of 60 unrelated Iranian CF patients were sequenced to identify disease-causing mutations. Eleven core haplotypes of CFTR were identified by genotyping six(More)
This study investigated whether motor set, in conjunction with spatial selective attention (sensory set), influences the transmission of incoming visual information at a precortical level in humans. Stimuli were presented concomitantly in both the right and left visual fields while subjects attended to the relevant visual field (either left or right) on a(More)
Through an affinity chromatography based modification-interference assay, we have identified chemical groups within Escherichia coli 16S ribosomal RNA sequence that are required for binding the aminoglycoside antibiotic paromomycin. Paromomycin was covalently linked to solid support via a nine atom spacer from the 6"'-amine of ring IV, and chemical(More)
The question of whether subcortical gating occurs as a function of spatial selective attention remains unsettled. This issue was investigated, using the paradigm of Eason et al. (1969) wherein subjects are instructed to attend to a specified location in a given visual field while attempting to ignore stimuli presented in the opposite field. Visual evoked(More)
Aminoglycoside antibiotics specifically interact with a variety of RNA sequences, and in particular with the decoding region of 16S ribosomal RNA in the aminoacyl tRNA acceptor site (A-site). Ring II of aminoglycosides (2-deoxystreptamine) is the most conserved element among aminoglycoside antibiotics that bind to the A-site. NMR structures of(More)
Pyrosequencing is a relatively recent method for sequencing short stretches of DNA. Because both Pyrosequencing and Sanger dideoxy sequencing were recently used to characterize and validate DNA molecular barcodes in a large yeast gene-deletion project, a meta-analysis of those data allow an excellent and timely opportunity for evaluating Pyrosequencing(More)