Robert G. Carroll

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PURPOSE Treatment with aromatase inhibitors decreases bone mineral density (BMD) and may increase the risk of fractures in postmenopausal women with early-stage breast cancer. The addition of zoledronic acid to adjuvant letrozole therapy may protect against bone loss. PATIENTS AND METHODS Patients receiving adjuvant letrozole were randomly assigned to(More)
The interaction between angiotensin II (ANG II) and catecholamines was examined in nonmammalian vertebrates. ANG II challenge caused a significant pressor response in representatives of the seven vertebrate classes. Additionally, plasma levels of both epinephrine and norepinephrine increased following intravascular ANG II injection in the conscious(More)
Anterior knee pain is commonly associated with patellofemoral malalignment. Both conventional radiographic measurements and CT measurements have been proposed to define and confirm the sometimes difficult clinical diagnosis of anterior knee pain secondary to patellofemoral malalignment. Using CT imaging with computerized technique to measure anatomic(More)
Our previous findings have shown that ethanol attenuates the decreases in plasma norepinephrine (NE) levels, and blood pressure elicited by centrally acting antihypertensive drugs in spontaneously hypertensive rats (SHRs). The present study investigated whether this interaction can be influenced by baseline blood pressure (BP) and sought direct evidence to(More)
The mechanism by which angiotensin II (AII) exerts its pressor effect was examined in a saltwater teleost and elasmobranch. In vivo application of AII failed to elicit any changes in dogfish (Squalus acanthias) mesenteric microcirculatory blood flow, but the sculpin (Myoxocephalus octodecimspinosus) mesentery bed showed consistent reversible decreases in(More)
OBJECTIVE To evaluate the impact of oral magnesium supplementation on risk factors for end-organ disease in patients with non-insulin-dependent diabetes mellitus (NIDDM). DESIGN A 16-week randomized, double-blind, placebo-controlled crossover trial. SETTING Outpatient center of an academic family medicine residency program. PATIENTS Twenty-eight(More)
Hemorrhage in rats causes a drop in body core temperature that is proportional to the hemorrhage volume. We tested the hypothesis that the hemorrhagic hypothermia is due to a downward shift in the thermoregulatory set point. If so, rats subjected to hemorrhage would prefer a cooler ambient temperature to enhance heat loss during the posthemorrhage period.(More)
Global Ischemia in Dogs: Intracranial Pressures, Brain Blood Flow and Metabolism • Our earlier studies showed no secondary postischemic (PI) rise in cisterna magna pressure (CMP) for ten hours and no significant reduction in CBF (integrated N,O desaturation technique) for three and one-half hours after 15 minutes of systemic circulatory arrest. However,(More)
Venous air embolism during neurosurgical procedures (detected by Doppler Ultrasound and aspiration via a right atrial catheter) was noted in 100 of 400 patients in the sitting position, 5 of 60 patients in the lateral position, 7 of 48 patients in the supine position, and 1 of 10 individuals monitored in the prone position. We confirmed venous air embolism(More)
METHODS Thirty-two patients with clinical node-negative breast cancer underwent sentinel node localization study as part of a National Cancer Institute-sponsored multicenter trial. Anatomical and histopathologic characteristics of sentinel lymph node (SLN) and a kinetic analysis of nodal uptake were studied. Patients were injected with 1 mCi/4 ml unfiltered(More)