Robert Franz

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The equipment modifications and process changes necessary to perform hot-melt particle coating in a fluid bed granulator are reviewed. A specific case is presented in which partially hydrogenated cottonseed oil is coated onto fine granules (mean particle size, 77 µm; range, 10–150 µm; one standard deviation is 10 µm) composed of a hydrophobic drug and(More)
A quasi chemical vapor deposition method for the manufacture of well-defined covalent triazine framework (CTF) coatings on cordierite monoliths is reported. The resulting supported porous organic polymer is an excellent support for the immobilization of two different homogeneous catalysts: (1) an IrIIICp*-based catalyst for the hydrogen production from(More)
Fluphenazine dihydrochloride and promethazine hydrochloride were adsorbed in vitro from suspensions of the tableting excipient, microcrystalline cellulose. Studies were undertaken to determine how this adsorption phenomenon was affected by the type of phenothiazine derivative, the type of microcrystalline cellulose, and pH and ionic strength adjustment. The(More)
The most important objective in the treatment of heatstroke and related conditions is to reduce the body core temperature to safe levels. Subjects performed at an external work rate of 54 W in hot, humid conditions (dry-bulb 40 degrees C, wet-bulb 35 degrees C), and a recent innovation to achieve body cooling, i.e. strategically placing instant cold packs(More)
A simulation model and a subsequent computer program were developed as experimentation methods for evaluating tableting processes with respect to cost. These methods also allow estimation of the various times involved in a tableting operation (e.g., the processing time). The model was programmed in FORTRAN using the GASP IV simulation language. After(More)
External gamma scintigraphy was used to monitor the gastrointestinal (GI) transit of radiolabeled sustained-release tablets containing 800 mg ibuprofen in eight fasted healthy volunteers. Ibuprofen serum concentrations were determined from blood samples drawn sequentially over a 24-hr period. Serum concentrations and related parameters were correlated to(More)
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