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OBJECTIVE To delineate the frequency, course, risk factors, and neuroanatomy of hemispatial neglect in a large stroke cohort. METHODS One thousand two hundred eighty-one patients with acute stroke were enrolled in a multicenter trial of an anticoagulant. Presence and severity of neglect were assessed with the NIH Stroke Scale (NIHSS) neglect item,(More)
OBJECTIVE To compare the baseline National Institutes of Health Stroke Scale (NIHSS) score and the Trial of Org 10172 in Acute Stroke Treatment (TOAST) stroke subtype as predictors of outcomes at 7 days and 3 months after ischemic stroke. METHODS Using data collected from 1,281 patients enrolled in a clinical trial, subtype of stroke was categorized using(More)
This Phase I trial evaluated the interaction between modafinil steady-state and cocaine. Twelve non-treatment seeking, cocaine dependent volunteers received four sets of randomized blinded infusions of saline, 20 mg IV cocaine, and 40 mg IV cocaine. Modafinil was given open label at 0 mg, 400 mg, or 800 mg. Modafinil combined with IV cocaine did not result(More)
A modification of the rank analysis of covariance, suitable for randomly right-censored dependent variate observations, is proposed and studied. The test suggested is based on an appropriate permutation distribution of the rank scores, and for large samples may be conducted by using the chi square distribution. The principal assumptions are that both(More)
OBJECTIVE Prior research suggesting a relationship between pancreatic cancer and depression conducted on clinical populations has been subject to recall bias. We reexamined this association using longitudinal population-based data. METHODS This was a retrospective cohort study using longitudinal insurance claims data. RESULTS Men with mental disorders(More)
Large research projects offer significant advantages for research, but they pose special data quality problems. Data gathered in such projects may contain a greater absolute number of mistakes because of the people collecting data, the complexity of data processing, and the collation required. We wanted to learn from the types and frequencies of errors(More)
Causes of death were studied in a cohort of 200 schizophrenic, 100 manic, and 225 depressive patients who were followed in a historical prospective study. These patients were admitted between 1934 and 1944 and were studied 30 to 40 years later. Five cause of death categories were considered in this analysis: (1) unnatural deaths, (2) neoplasms, (3) diseases(More)
To test interphysician agreement on the diagnosis of subtype of ischemic stroke, we sent subtype definitions and 18 case summaries (clinical features and pertinent laboratory data) to 24 neurologists who have a special interest in stroke, and asked them to determine the most likely subtype diagnosis. The overall agreement was 0.64 (Kappa [K] = 0.54).(More)
OBJECTIVE To study the relation between acute blood glucose level and outcome from ischemic stroke. BACKGROUND Hyperglycemia may augment acute ischemic brain injury and increase the risk of hemorrhagic transformation of the infarct. METHODS The authors analyzed the relation between admission blood glucose level (within 24 hours from ischemic stroke(More)
We conducted a 30- to 40-year field follow-up of 685 patients with schizophrenia, affective disorders, and nonpsychiatric conditions. Long-term outcome was analyzed in terms of the patients' marital, residential, occupational, and psychiatric status. On the whole, psychiatric patients showed a significantly poorer outcome than the surgical controls. On the(More)