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OBJECTIVE Drugs have tremendous potential to cure and relieve disease, but the risk of unintended effects is always present. Healthcare providers increasingly record data in electronic patient records (EPRs), in which we aim to identify possible adverse events (AEs) and, specifically, possible adverse drug events (ADEs). MATERIALS AND METHODS Based on the(More)
A key prerequisite for precision medicine is the estimation of disease progression from the current patient state. Disease correlations and temporal disease progression (trajectories) have mainly been analysed with focus on a small number of diseases or using large-scale approaches without time consideration, exceeding a few years. So far, no large-scale(More)
BACKGROUND Data collected for medical, filing and administrative purposes in electronic patient records (EPRs) represent a rich source of individualised clinical data, which has great potential for improved detection of patients experiencing adverse drug reactions (ADRs), across all approved drugs and across all indication areas. OBJECTIVES The aim of(More)
An electronic nose is used to monitor the bioreactor off-gas composition in perfused cultivations of a CHO-cell line producing recombinant human blood coagulation factor VIII. The applicability of the electronic nose for monitoring cellular state transitions and process control is explained. It is shown that the instrument can reveal characteristic process(More)
Systems for the preparation and administration of drugs are designed to ensure that the drug is not contaminated. They do not necessarily consider the work environment for the medical staff and new techniques are therefore desirable. The aim of this work is to compare a new closed system for the preparation and administration of drugs with the traditional(More)
Keywords: Trajectory sensitivity analysis (TSA) Transient stability Small signal stability Flexible AC transmission system (FACTS) devices Critical clearing time (CCT) a b s t r a c t This paper proposes an approach based on trajectory sensitivity analysis (TSA) to find most suitable placement of series compensators in the power system. The main objective(More)
e present a simplified dual-channel discrimination model with spatio-temporal filters to represent the t s visual system contrast sensitivity, and masking based on local spatio-temporal contrast energy. The contras ensitivity filter parameters of the model were based on previous work. The masking and global sensitivity h t parameters are calibrated to(More)