Robert Elliott Smith

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Specifically, we apply genetic algorithms that include diploid genotypes and dominance operators to a simple nonstationary problem in function optimization: an oscillating, blind knapsack problem. In doing this, we find that diploidy and dominance induce a form of long term distributed memory that stores and occasionally remembers good partial solutions(More)
This paper describes an immune system model based on binary strings. The purpose of the model is to study the pattern recognition processes and learning that take place at both the individual and species levels in the immune system. The genetic algorithm (GA) is a central component of the model. The paper reports simulation experiments on two pattern(More)
Diffusion MRI streamlines tractography suffers from a number of inherent limitations, one of which is the accurate determination of when streamlines should be terminated. Use of an accurate streamlines propagation mask from segmentation of an anatomical image confines the streamlines to the volume of the brain white matter, but does not take full advantage(More)
Diffusion MRI streamlines tractography is increasingly being used to characterise and assess the structural connectome of the human brain. However, issues pertaining to quantification of structural connectivity using streamlines reconstructions are well-established in the field, and therefore the validity of any conclusions that may be drawn from these(More)
We propose that bio-inspired algorithms are best developed and analysed in the context of a multidisciplinary conceptual framework that provides for sophisticated biological models and well-founded analytical principles, and we outline such a framework here, in the context of Artificial Immune System (AIS) network models, and we discuss mathematical(More)
Diffusion MRI allows the structural connectivity of the whole brain (the 'tractogram') to be estimated in vivo non-invasively using streamline tractography. The biological accuracy of these data sets is however limited by the inherent biases associated with the reconstruction method. Here we propose a method to retrospectively improve the accuracy of these(More)