Learn More
The systematic translation of cancer genomic data into knowledge of tumour biology and therapeutic possibilities remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect the genomic diversity of human cancers and for which detailed genetic and pharmacological annotation is available. Here we describe the(More)
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has been validated by the success of RAF and(More)
Research was conducted to determine how well subjects could distinguish between surfaces with different coefficient of friction (COF) values and to evaluate how well subjective ratings of slipperiness correlated with the actual COF values. Thirty-three ironworkers experienced in working and walking on steel surfaces and 23 university students inexperienced(More)
The purpose of this article is to outline critical elements in the development and quality assurance (QA) assessment of a computer-based assessment battery (CAB). The first section of the article provides an overview of the life cycle of a representative CAB, typical evolutionary stages, and many of the essential considerations for designing and developing(More)
The impact of microgravity and other stressors on cognitive performance need to be quantified before long duration space flights are planned or attempted since countermeasures may be required. Four astronauts completed 38 sessions of a 20-minute battery of six cognitive performance tests on a laptop computer. Twenty-four sessions were preflight, 9 sessions(More)
The systematic translation of cancer genomic data into knowledge of tumor biology and therapeutic avenues remains challenging. Such efforts should be greatly aided by robust preclinical model systems that reflect the genomic diversity of human cancers and for which detailed genetic and pharmacologic annotation is available 1. Here we describe the Cancer(More)
PIK3CA gain-of-function mutations are a common oncogenic event in human malignancy 1–4 , making PI3K an attractive target for cancer therapy. Despite the great promise of targeted therapy, resistance often develops, resulting in treatment failure. To elucidate mechanisms of resistance to PI3K-targeted therapy, we constructed a mouse model of breast cancer(More)
The Pap test has effectively reduced the incidence and mortality of cervical cancer. However, because of the morphological basis of this test, sensitivity and specificity are less than ideal, a situation that complicates the clinical management of women diagnosed with low-grade cervical abnormalities. In an attempt to understand the molecular basis of(More)
The reliability and construct validity of the Automated Neuropsychological Assessment Metrics (ANAM) mood scale (AMS) were examined using concurrent, well-validated measures of mood and confirmatory factor analysis (CFA) with a sample of 210 volunteer college students. The AMS was given in computerized format with multiple adjectives using a visual analog(More)
The current study examined the performance of active duty soldiers on the Automated Neuropsychological Assessment Metrics (ANAM) traumatic brain injury test battery, to expand the reference data for use in military settings. The effects of age and gender on cognitive performance also were explored. The ANAM traumatic brain injury battery, consisting of six(More)