Robert E. Kearney

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The dynamics of joint mechanics are a fundamental characteristic of the motor system. They determine the displacements evoked by perturbing forces during postural control and the forces that must be generated to perform a voluntary movement. This article reviews experimental studies of these dynamics, with an emphasis on the behavior of single joints in(More)
We have investigated the ability of humans to stabilize their heads in space and assessed the influence of mental set and the relative importance of visual and vestibular cues. Ten normal subjects and 3 patients with bilateral vestibular loss were studied. Subjects were fixed firmly to the chair of a turntable facing a screen on which was projected a target(More)
We report more than 1400 proteins of the secretory-pathway proteome and provide spatial information on the relative presence of each protein in the rough and smooth ER Golgi cisternae and Golgi-derived COPI vesicles. The data support a role for COPI vesicles in recycling and cisternal maturation, showing that Golgi-resident proteins are present at a higher(More)
The left foot of five human subjects was rotated in a fixed stochastic pattern about a constant ankle angle and the forces opposing these perturbations were measured. The dynamic stiffness transfer functions relating ankle angular position to ankle torque were calculated. Stiffness gain was flat at low frequencies, had a resonant valley at intermediate(More)
1. Pulse inputs (similar to tendon jerks) were applied to the human ankle joint with the use of a hydraulic actuator. Inputs of only 1-2 degrees could elicit large responses (> 20% of maximum voluntary contraction). The magnitude of the response depended nonlinearly on a number of factors: the amplitude, direction, and duration of the pulse; the angle of(More)
Focal cortical dysplasia (FCD), a malformation of cortical development, is a frequent cause of pharmacologically intractable epilepsy. FCD is characterized on Tl-weighted MRI by cortical thickening, blurring of the gray-matter/white-matter interface, and gray-level hyperintensity. We have previously used computational models of these characteristics to(More)
It is argued that there are a number of situations in life science where it is desirable to attempt a two-sided linear filter identification. A simple method is presented for the determination of a nonparametric, two-sided linear filter from system input and output data. The time-domain filter is determined from a matrix equation involving the input(More)
The left foot of five normal human subjects was rotated in a fixed stochastic pattern about a constant ankle angle and the torques opposing these rotations were measured. The dynamic stiffness transfer functions relating ankle angular position to ankle torque were calculated. Stiffness gain was flat at low frequencies, had a resonant valley at intermediate(More)
Tandem MS has identified 209 proteins of clathrin-coated vesicles (CCVs) isolated from rat brain. An overwhelming abundance of peptides were assigned to the clathrin coat with a 1:1 stoichiometry observed for clathrin heavy and light chains and a 2:1 stoichiometry of clathrin heavy chain with clathrin adaptor protein heterotetramers. Thirty-two proteins(More)
The theory underlying a new method for the identification of time-varying systems is described. The method uses singular value decomposition to obtain least-squares estimates of time-varying impulse response functions from an ensemble of input-output realizations. No a priori assumptions regarding the system structure or form of the time-variation are(More)