Robert E. Garfield

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OBJECTIVE To use artificial neural networks (ANNs) on uterine electromyography (EMG) data to classify term/preterm labor/non-labor pregnant patients. MATERIALS AND METHODS A total of 134 term and 51 preterm women (all ultimately delivered spontaneously) were included. Uterine EMG was measured trans-abdominally using surface electrodes. "Bursts" of(More)
Diabetic gastroparesis is a disorder that predominantly affects women. However, the biological basis of this sex bias remains completely unknown. In this study we tested the hypothesis that a component of this effect may be mediated by the nitrergic inhibitory system of the enteric nervous system. Age-matched male and female Sprague-Dawley rats were studied(More)
BACKGROUND Preterm birth is the primary cause of the neonatal mortality and morbidity. There will be no preterm birth without a cervical softening. Nitric oxide (NO) is shown to be a mediator of term cervical ripening. The aim of this study was to investigate mRNA expression of the three isomers of NO synthases (NOS) and to identify them by(More)
Non-selective cation channel (NSCC) currents were identified in myometrial smooth muscle cells isolated from pregnant rats (day 18-20) using the whole-cell patch clamp method. NSCC currents had a linear current/voltage relationship and were time independent. Reduction of extracellular Na(+) substantially decreased the amplitude of NSCC currents, indicating(More)
The present work seeks to determine if a particular non-linear analytic method is effective at quantifying uterine electromyography (EMG) data for estimating the onset of labor. Twenty-seven patients were included, and their uterine EMG was recorded non-invasively for 30 min. The patients were grouped into two sets: G1: labor, N = 14; G2: antepartum, N =(More)
Progesterone is more than a progestin. Beyond functions in cycle and pregnancy, progesterone binds with high affinity to the mineralocorticoid receptor (MR) acting as an antagonist, with obvious significance for electrolyte homeostasis, an array of MR-related functions in the circulation as well as in the CNS. Progesterone induces natriuresis at(More)
Is knowledge of the pattern of electrical activity in the pregnant uterus helpful to our understanding of uterine function? Focus on " Patterns of electrical propagation in the intact pregnant guinea pig uterus " by Lammers et al. IT HAS BEEN RECOGNIZED FOR more than 60 years that electrical activity of the myometrium is the fundamental mechanism(More)
Antiprogestins with a 4' para imidazolylphenyl moiety were synthesized and their biochemical interactions with the progesterone and glucocorticoid receptor were investigated. Depending on the substitution pattern at the 17 position partial progesterone receptor (PR)-agonistic derivatives like compounds EC339 and EC336 or pure antagonists like compound EC317(More)
Progesterone receptor (PR) plays a key role in reproductive functions, and compounds that inhibit progesterone action (antiprogestins) have potential use in the treatment of estrogen- and progesterone-dependent diseases, including uterine leiomyomas and breast cancer. In the present study, we chemically synthesized novel 17-fluorinated steroids and(More)
A decline in serum progesterone or antagonism of progesterone receptor function results in preterm labor and birth. Whether characteristics of premature remodeling of the cervix after antiprogestins or ovariectomy are similar to that at term was the focus of the present study. Groups of pregnant rats were treated with vehicle, a progesterone receptor(More)