Robert E. Garfield

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OBJECTIVE Power spectrum (PS) of uterine electromyography (EMG) can identify true labor. EMG propagation velocity (PV) to diagnose labor has not been reported. The objective was to compare uterine EMG against current methods to predict preterm delivery. STUDY DESIGN EMG was recorded in 116 patients (preterm labor, n = 20; preterm nonlabor, n = 68; term(More)
OBJECTIVE To determine whether delivery can be predicted using transabdominal uterine electromyography. METHODS A total of 99 patients were grouped as either term (37 weeks or more) or preterm (less than 37 weeks). Uterine electrical activity was recorded for 30 minutes in clinic. Electromyographic "bursts" were evaluated to determine the power density(More)
OBJECTIVE To validate the possibility that human uterine electrical events (electromyographic signals) can be recorded and characterized from the abdominal surface during pregnancy. METHODS The gestational ages ranged from 20 to 43 weeks. The study included patients at term but not in labor, patients in active labor (term and preterm), postpartum(More)
Preterm labour and resultant preterm birth are the most important problems in perinatology. Countless efforts have failed to establish a single effective treatment of preterm labour, partly because the mechanisms regulating the uterus and cervix during pregnancy are not well understood. New knowledge is needed to inhibit early progression of labour (uterine(More)
To use artificial neural networks (ANNs) on uterine electromyography (EMG) data to classify term/preterm labor/non-labor pregnant patients. A total of 134 term and 51 preterm women (all ultimately delivered spontaneously) were included. Uterine EMG was measured trans-abdominally using surface electrodes. “Bursts” of elevated uterine EMG, corresponding to(More)
Thin sections of longitudinal and circular muscle of myometrium obtained from rats during pregnancy, at term, during delivery, and postpartum were quantitatively examined in the electron microscope. Gap junctions (low resistance pathways) were only present during or immediately prior to delivery and immediately postpartum. The absence of gap junctions(More)
Presently, there is no effective treatment for preterm labor. The most obvious reason for this anomaly is that there is no objective manner to evaluate the progression of pregnancy through steps leading to labor, either at term or preterm. Several techniques have been adopted to monitor labor, and/or to diagnose labor, but they are either subjective or(More)
The hypothesis that gap junction (GJ) formation between myometrial cells at term improves electrical coupling was tested. We measured the spread of electrical excitation from six extracellular electrodes aligned on uterine strips in either the longitudinal (axial) or transverse (circumferential) direction. Spontaneous bursts propagated over the entire 15-mm(More)
Nitric oxide (NO) is a major paracrine mediator and important regulatory agent in various female reproductive processes, such as ovulation, implantation, pregnancy maintenance, labor and delivery. Ovulation: Circulating NO-products are increased during follicle development and decreased right after ovulation. INOS-inhibition results in a 50% reduction of(More)