Robert E. Garfield

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OBJECTIVE To use artificial neural networks (ANNs) on uterine electromyography (EMG) data to classify term/preterm labor/non-labor pregnant patients. MATERIALS AND METHODS A total of 134 term and 51 preterm women (all ultimately delivered spontaneously) were included. Uterine EMG was measured trans-abdominally using surface electrodes. "Bursts" of(More)
BACKGROUND Preterm birth is the primary cause of the neonatal mortality and morbidity. There will be no preterm birth without a cervical softening. Nitric oxide (NO) is shown to be a mediator of term cervical ripening. The aim of this study was to investigate mRNA expression of the three isomers of NO synthases (NOS) and to identify them by(More)
The present work seeks to determine if a particular non-linear analytic method is effective at quantifying uterine electromyography (EMG) data for estimating the onset of labor. Twenty-seven patients were included, and their uterine EMG was recorded non-invasively for 30 min. The patients were grouped into two sets: G1: labor, N = 14; G2: antepartum, N =(More)
A decline in serum progesterone or antagonism of progesterone receptor function results in preterm labor and birth. Whether characteristics of premature remodeling of the cervix after antiprogestins or ovariectomy are similar to that at term was the focus of the present study. Groups of pregnant rats were treated with vehicle, a progesterone receptor(More)
Non-selective cation channel (NSCC) currents were identified in myometrial smooth muscle cells isolated from pregnant rats (day 18-20) using the whole-cell patch clamp method. NSCC currents had a linear current/voltage relationship and were time independent. Reduction of extracellular Na(+) substantially decreased the amplitude of NSCC currents, indicating(More)
The smooth muscle cells of the uterus contract in unison during delivery. These cells achieve coordinated activity via electrical connections called gap junctions which consist of aggregated connexin proteins such as connexin43 and connexin45. The density of gap junctions governs the excitability of the myometrium (among other factors). An increase in gap(More)
Parturition involves increasing compliance (ripening) of the uterine cervix and activation of the myometrium. These processes take place in a different time frame. Softening and shortening of the cervix starts in midpregnancy, while myometrial activation occurs relatively close to delivery. Methods currently available to clinicians to assess cervical and(More)
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