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OBJECTIVE To determine whether delivery can be predicted using transabdominal uterine electromyography. METHODS A total of 99 patients were grouped as either term (37 weeks or more) or preterm (less than 37 weeks). Uterine electrical activity was recorded for 30 minutes in clinic. Electromyographic "bursts" were evaluated to determine the power density(More)
Nitric oxide (NO) is considered to be an important local mediator that suppresses uterine contractility in rats and rabbits during pregnancy until term. The aim of this study was to investigate the mRNA concentrations for the three isoforms of nitric oxide synthase (NOS) in rat uterus and cervix and to determine whether alterations occur in association with(More)
OBJECTIVE To validate the possibility that human uterine electrical events (electromyographic signals) can be recorded and characterized from the abdominal surface during pregnancy. METHODS The gestational ages ranged from 20 to 43 weeks. The study included patients at term but not in labor, patients in active labor (term and preterm), postpartum(More)
Diabetic gastroparesis is a disorder that predominantly affects women. However, the biological basis of this sex bias remains completely unknown. In this study we tested the hypothesis that a component of this effect may be mediated by the nitrergic inhibitory system of the enteric nervous system. Age-matched male and female Sprague-Dawley rats were studied(More)
Current methodologies to assess the process of labor, such as tocodynamometry or intrauterine pressure catheters, fetal fibronectin, cervical length measurement and digital cervical examination, have several major drawbacks. They only measure the onset of labor indirectly and do not detect cellular changes characteristic of true labor. Consequently, their(More)
Morphometric measurements at the electron microscope level were carried out on three categories of mesenteric arteries representing elastic (superior mesenteric), muscular and arteriolar vessels, from 10- to 12-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto normotensive rats (WKY). Changes were observed only in muscular and(More)
The hypothesis that gap junction (GJ) formation between myometrial cells at term improves electrical coupling was tested. We measured the spread of electrical excitation from six extracellular electrodes aligned on uterine strips in either the longitudinal (axial) or transverse (circumferential) direction. Spontaneous bursts propagated over the entire 15-mm(More)
OBJECTIVE Power spectrum (PS) of uterine electromyography (EMG) can identify true labor. EMG propagation velocity (PV) to diagnose labor has not been reported. The objective was to compare uterine EMG against current methods to predict preterm delivery. STUDY DESIGN EMG was recorded in 116 patients (preterm labor, n = 20; preterm nonlabor, n = 68; term(More)
To use artificial neural networks (ANNs) on uterine electromyography (EMG) data to classify term/preterm labor/non-labor pregnant patients. A total of 134 term and 51 preterm women (all ultimately delivered spontaneously) were included. Uterine EMG was measured trans-abdominally using surface electrodes. “Bursts” of elevated uterine EMG, corresponding to(More)
The aim of this study was to determine if nitric oxide (NO) production and nitric oxide synthase (NOS) isoforms change within the uterus and cervix during pregnancy and labour either at term or preterm. NO production was compared in the rat uterus and cervix of non-pregnant and pregnant rats on days 18-22 prior to labour, day 22 during delivery, 1 day(More)