Robert Dix

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The effects of food and sucralfate on the pharmacokinetics of levofloxacin following the administration of a single 500-mg oral dose were investigated in a randomized, three-way crossover study with young healthy subjects (12 males and 12 females). Levofloxacin was administered under three conditions: fasting, fed (immediately after a standardized high-fat(More)
In a retrospective study in rural Zaire, 10.2% of all deliveries were conducted by cesarean section. Common indications were contracted pelvis and uterine dysfunction (37%) and previous cesarean delivery (32%). Compared with normal delivery, mortality was higher after cesarean section. Cesarean section should only be performed by well-trained personnel and(More)
STUDY OBJECTIVE To evaluate the pulmonary tissue distribution of levofloxacin, the new once-daily fluoroquinolone, after a single 500-mg oral dose. DESIGN Open-label study. SETTING One pulmonary clinic and two university-affiliated teaching hospitals. PATIENTS Eighteen adults undergoing lung biopsy or lobectomy. INTERVENTIONS Levofloxacin plasma and(More)
We examined if inhibition of endogenous prostaglandin (PG) synthesis reduced the severity of ventricular arrhythmia and the incidence of ventricular fibrillation (VF) following occlusion of the left anterior descending coronary artery (LAD) in anesthetized cats. We also determined whether the PGs were interacting in a facilitory manner with the sympathetic(More)
Clinical reports indicate that cessation of treatment with the antihypertensive agent clonidine is associated with a withdrawal syndrome which may include a hypertensive overshoot of critical proportions. We have attempted to produce an animal model of this syndrome in rats. Rats were treated with clonidine in the drinking water (5 microgram/ml; total dose(More)
Plasma intact 14C-mixidine levels in rats increased when the drug was administered intraduodenally with 1:3 and 1:5 molar ratios of 2-naphthalenesulfonic acid. Upon histological examination of the duodenums, similar doses of mixidine combined with 2-naphthalenesulfonic acid produced no dose-related lesions. These and previous observations demonstrate that(More)
The efficacy and safety of prazosin GITS (gastro-intestinal therapeutic system), a new extended-release once-a-day formulation, were assessed both as monotherapy in mild essential hypertension and in combination with a diuretic in moderate essential hypertension in two multicenter, double-blind, placebo-controlled trials. Prazosin GITS (Minipress XL) given(More)
1 The fact that the majority of reported damaging attacks have little sophistication leads to the logical question of why the $15 billion annual investment in cyber security protection by United States Organizations is not more effective in successfully blocking these unsophisticated attacks. The Problem Conservatively, $15 billion is spent each year by(More)