Robert Dennhardt

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After brain death, 32 potential organ donors were studied to determine serum and plasma concentrations of hypothalamic-pituitary hormones, thyroid hormones, and cortisol over a period of up to 80 hr. Diagnosis of brain death was established either on the basis of clinical criteria (n = 16) or by angiography (n = 16). While 78% of the organ donors developed(More)
The incidence of increased drug metabolism activity as a consequence of multiple drug therapy at a surgical intensive care ward has been studied non-invasively by determinations of daily urinary D-glucaric acid (GA) excretion rates. Among 165 randomly selected patients, GA excretion was stimulated in 76 cases (= 46%). Exploratory data analysis showed that(More)
Pentobarbital plasma levels were determined in 16 critical care patients receiving a dose of approximately 30 mg/kg/day and suffering from severe head injury. In 10 patients monitored more than six times, a continuous decrease in plasma concentrations, caused by a mean increase in pentobarbital total plasma clearance from 0.81 to 1.06 ml/min/kg, was found.(More)
A multicentre open trial included 219 hospitalized patients suffering from various Gram-positive infections. Previous antimicrobial therapy had been carried out in 37% of patients. The initial teicoplanin dose was 400 mg for 77.6% and 800 mg for 12.6% of the patients, 9.8% received other initial doses. The dose on subsequent days was 200 mg or less for 63%(More)
For a period of five days serum levels of antidiuretic hormone (ADH) have been investigated postoperatively in a group of 20 patients with upper abdominal surgery. In addition serum electrolytes (Na+, K+) and plasma osmolality have been controlled regularly. Patients in group A (n = 10) received Fentanyl epidurally (0.1-0.2 mg diluted with 0.9% saline(More)
Intensive care patients develop altered patterns of behaviour for a variety of reasons. However, the drug therapy instituted to ameliorate these psychoreactive problems may give rise to complications such as the central anticholinergic syndrome. Cholinergic receptors are scattered at random throughout the central nervous system. The depression of(More)
The secretion of antidiuretic hormone (ADH) is mainly influenced by changes in osmolality and blood volume. In addition stress and surgical trauma may cause an elevation in plasma-ADH levels. In 20 patients scheduled for similar surgical procedures two different anaesthesia techniques were applied: in group 1 (n = 10) a combination of peridural anaesthesia(More)
The effect of pentobarbital treatment in a mean dose of 30 mg/kg/day on the clearance of hexobarbital (Evipan) and dipyrone (Novalgin) has been evaluated in critical care patients receiving a large number of drugs as comedication. Eleven patients treated with pentobarbital showed a hexobarbital half-life of 2.79 h and a total plasma clearance of 9.80(More)