Kwan Hur8
C Hendricks Brown7
J John Mann7
8Kwan Hur
7C Hendricks Brown
7J John Mann
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We develop simultaneous approximate statistical prediction limits for a gamma-distributed random variable. Specifically, we develop an upper prediction limit (UPL) for p of m future samples at each of r locations, based on a previous sample of n measurements. A typical example is the environmental monitoring problem in which the distribution of an analyte(More)
In this paper, we propose an approach to modeling functional magnetic resonance imaging (fMRI) data that combines hierarchical polynomial models, Bayes estimation, and clustering. A cubic polynomial is used to fit the voxel time courses of event-related design experiments. The coefficients of the polynomials are estimated by Bayes estimation, in a two-level(More)
OBJECTIVE In 2003 and 2004, U.S. and European regulators issued public health warnings about a possible association between antidepressants and suicidal thinking and behavior. The authors assessed whether these warnings discouraged use of antidepressants in children and adolescents and whether they led to increases in suicide rates as a result of untreated(More)
In this review, we explore recent developments in the area of linear and nonlinear generalized mixed-effects regression models and various alternatives, including generalized estimating equations for analysis of longitudinal data. Methods are described for continuous and normally distributed as well as categorical (binary, ordinal, nominal) and count(More)
CONTEXT Some meta-analyses suggest that efficacy of antidepressants for major depression is overstated and limited to severe depression. OBJECTIVE To determine the short-term efficacy of antidepressants for treating major depressive disorder in youth, adult, and geriatric populations. DATA SOURCES Reanalysis of all intent-to-treat person-level(More)
CONTEXT The US Food and Drug Administration issued a black box warning for antidepressants and suicidal thoughts and behavior in children and young adults. OBJECTIVE To determine the short-term safety of antidepressants by standard assessments of suicidal thoughts and behavior in youth, adult, and geriatric populations and the mediating effect of changes(More)
OBJECTIVE In 2002, 264 children and adolescents ages 5-14 died by suicide in the United States, the fifth leading cause of death. Of these suicides, 260 were in the 10-14 year age group, making suicide the third largest cause of death behind accidents and malignancy. Although 60% of suicides in the general population occur in the midst of a mood disorder,(More)
Competing item response theory (IRT) models were used to test the factor structure of the psychiatric diagnostic screening questionnaire (PDSQ; Zimmerman M, Mattia JI. A self-report scale to help make psychiatric diagnoses: the psychiatric diagnostic screening questionnaire. Archives of General Psychiatry 2001;58:787-94), a self-report psychiatric measure(More)
CONTEXT On January 31, 2008, the Food and Drug Administration issued an alert regarding increased risk of suicidal thoughts and behavior related to use of antiepileptic drugs (AEDs). On July 10, 2008, a Food and Drug Administration scientific advisory committee voted that, yes, there was a significant positive association between AEDs and suicidality but(More)
OBJECTIVE This study investigated the combination of item response theory and computerized adaptive testing (CAT) for psychiatric measurement as a means of reducing the burden of research and clinical assessments. METHODS Data were from 800 participants in outpatient treatment for a mood or anxiety disorder; they completed 616 items of the 626-item Mood(More)