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  • Martin Allan, Sukhdev Manku, +11 authors Amal Wahhab
  • Medicine, Chemistry
  • Bioorganic & medicinal chemistry letters
  • 2009 (First Publication: 15 February 2009)
  • A series of N-benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides targeting co-activator associated arginine methyltransferase 1 (CARM1) have been designed and synthesized. The potencyExpand
  • S. Raeppel, S. Claridge, +21 authors A. Vaisburg
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2009 (First Publication: 1 March 2009)
  • A series of N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting c-Met and VEGFR2 tyrosine kinases was designed and synthesized. TheExpand
  • Liang Tong, Chungeng Qian, Marie-Josée Massariol, Robert Déziel, Christiane Yoakim, Lisette Lagacé
  • Biology, Medicine
  • Nature Structural Biology
  • 1998 (First Publication: 1 September 1998)
  • Human cytomegalovirus (HCMV) protease belongs to a new class of serine proteases, with a unique polypeptide backbone fold. The crystal structure of the protease in complex with a peptidomimeticExpand
  • Steven R LaPlante, Pierre R. Bonneau, +6 authors Stephen H. Kawai
  • Chemistry
  • 1999 (First Publication: 1 April 1999)
  • The conformational properties of the N-tert-butylacetyl-l-tert-butylglycyl-l-Nδ,Nδ-dimethylasparagyl-l-alanyl methyl ketone (MK) 1 and its terminal N-isopropylacetyl analogue 2 were investigated.Expand