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IS research has been criticized for having little influence on practice. One approach to achieving more relevance is to conduct research using appropriate research methods that balance the interests of both researchers and practitioners. This paper examines the similarities between two methods that address this mandate by adopting a proactive stance to(More)
Toxoplasma gondii is a highly successful protozoan parasite in the phylum Apicomplexa, which contains numerous animal and human pathogens. T.gondii is amenable to cellular, biochemical, molecular and genetic studies, making it a model for the biology of this important group of parasites. To facilitate forward genetic analysis, we have developed a(More)
OBJECTIVES To establish the safety of an intranasal diamorphine (IND) spray in children. DESIGN An open-label, single-dose pharmacovigilance trial. SETTING Emergency departments in eight UK hospitals. PARTICIPANTS Children aged 2-16 years with a fracture or other trauma. OUTCOME MEASURES Adverse events (AE) specifically related to nasal irritation,(More)
BACKGROUND Type 2 diabetes mellitus (T2DM) has been associated with impairment of cognitive function. Studies show a strong negative correlation between the levels of glycosylated hemoglobin and cognitive function in adult patients above the mean age of 60 years. In healthy adults, age-related cognitive impairment is mostly reported after the age of 60(More)