Robert Clark

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A history of depression is a risk factor for Alzheimer's disease (AD), suggesting the possibility that antidepressants administered prophylactically might retard the disease process and preserve cognitive function. Here we report that pre-symptomatic treatment with the antidepressant paroxetine attenuates the disease process and improves cognitive(More)
Mutations in two genes, presenilin 1 (PS1) and presenilin 2, are linked to early onset cases of familial Alzheimer's disease. The presenilins are thought to contribute to the pathogenesis of Alzheimer's disease by directly or indirectly affecting the proteolytic processing of the amyloid precursor protein. They have also been implicated in the proteolytic(More)
The expression of the presenilin 1 (PS-1) gene has been investigated by in situ hybridization in early onset familial Alzheimer's disease (FAD), late onset Alzheimer's disease (AD) and normal control brain. Mutations in this gene are responsible for chromosome 14-linked FAD. We have found that presenilin 1 mRNA is present throughout the human brain with a(More)
This study investigates the effect of publicity on consumer demand. Although the marketing literature suggests that publicity can have an important influence on consumers' choices, only a few studies have attempted to quantify how media coverage can affect consumer demand. The main obstacle to measuring the impact of publicity is that data on media coverage(More)
  • Robert Boles, Robert F Clark, Roy Beckemeyer Quivira, Nwr Stafford, Sept, Roy Beckemeyer +1 other
  • 2012
The Kansas School Naturalist is sent free of charge and upon request to teachers, school administrators, public and school librarians, youth leaders, conservationists, and others interested in natural history and nature education. In-print back issues are sent free as long as supply lasts. Out-of-print back issues are sent for one dollar photocopy and(More)
Comments on draft reviews and the authors' responses to the comments are posted for public viewing on the Agency for Healthcare Research and Quality (AHRQ) Web site after the final research review is published. Comments are not edited for spelling, grammar, or other content errors. Each invited peer reviewer comment is listed anonymously. Peer reviewers'(More)
A false feedback paradigm was used to produce a discrepancy between expected and "actual" tumescence among 57 sexually dysfunctional and 58 sexually functional men randomly assigned to one of four false tumescence feedback conditions: negative (NEG), neutral (NEU), positive (POS), or no (NO) feedback. Participants predicted an erection score before viewing(More)
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