Robert C. Rosenberg

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Preparation of cobalt(II) derivatives of type 1 copper proteins has been extended to include bean plastocyanin and azurin from Pseudomonas aeruginosa. Fluorescence quenching data suggest that Co(II) binds to the type 1 site of both apoplastocyanin and apoazurin. Electronic absorption spectral measurements have been made for cobalt(II)-stellacyanin,(More)
The magnetic susceptibilities of cobalt(II) and nickel(II) derivaties of carboxypeptidase A (CPA) follow the Curie law over a wide temperature range. The observed magnetic moments of Co(II)CPA and Ni(II)CPA are 4.77 +/- 0.15 and 2.53 +/- 0.10 Bohr Magnetons, respectively. The magnetic and spectral properties of Ni(II)CPA are consistent only with an(More)
The single histidine residue (His-15) in hen egg white lysozyme (EC 3.2.1.17) was chemically modified by diethyl pyrocarbonate (DEPC) to form exclusively the mono-N-carbethoxyimidazole adduct (second order rate constant of 252 +/- 16 M-1 min-1). Irreversible biscarbethoxylation of the His-15 imidazole ring by DEPC was observed when lysozyme was pretreated(More)
The alternative electron donors ferrocyanide and hydroquinone have been shown to also act as inhibitors of dopamine-beta-hydroxylase (3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase (beta-hydroxylating), EC 1.14.17.1). Hydroquine shows uncompetitive inhibition with respect to ascorbate and competitive inhibition with respect to tyramine.(More)
In the title crystal structure, C(12)H(22)NOSi(+)·Cl(-), anions and cations are linked via O-H⋯Cl, N-H⋯Cl and N-H⋯O hydrogen bonds to form a two-dimensional network parallel to (101). Within the hydrogen-bonded network, R(4) (2)(22) ring motifs are stacked along [010].
The relationship between the endogenous cytoplasmic levels of the enzymes superoxide dismutase and catalase and the inhibition of cell proliferation by radiation has been studied in 11 mouse cell lines. The resistance of these mouse cell lines to radiation was found to vary by over 25-fold. No correlation was found between the cytoplasmic level of(More)
The metastable, reversible carbethoxylation of histidine in the cobalt(III) complexes (ethylene-diamine)(histidine)chlorocobalt(III) chloride, [Co(III)(en)ClHis]Cl, and (diethylenetriamine) (histidine)cobalt(III) dichloride, [Co(III)(dien)His]Cl2, following reaction with diethylpyrocarbonate, was observed using UV spectroscopy. These observations indicate(More)